RT3 Ratio of 90.. Although pretty sure I have high RT3

Maca

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Thyroid Labs

TSH - 1.33 uUI/ml ( 0.3 - 5.0 )
Free T4 - 1.33 ng/dl ( 0.8 - 2.0 )
Free T3 - 3.26 pg/ml ( 2.0 - 4.4 )
Reverse T3 - 0.36 ng/ml ( 0.09 - 0.35 )




Do I have an issue? I've had RT3 blood tests over a year now and typically this is the picture, RT3 at top of the range and Free T3 in the 2-3 range

Thanks in advance for any help!
 
For me, top-of-range rT3 seemed to be associated with a kind of fatigue that made it hard to do things. Selenium supplementation didn't resolve it, but low doses of T3 cut rT3 in half, and pretty much eliminated the symptoms with minimal suppression of endogenous T3.
 
Whether it needs lowered or not we're used to see RT3 with a lab range of like 10-25, where we would say >15 is a problem with potential pooling. Not sure how to apply that to your test result. on the high end of the lab range is probably not good in this care no matter the test.
 
For me, top-of-range rT3 seemed to be associated with a kind of fatigue that made it hard to do things. Selenium supplementation didn't resolve it, but low doses of T3 cut rT3 in half, and pretty much eliminated the symptoms with minimal suppression of endogenous T3.

When you say low doses what did you end up taking? Also how often did you dose? I've heard T3 has a short half-life and sometimes needs dosing multiple times a day.
 
Whether it needs lowered or not we're used to see RT3 with a lab range of like 10-25, where we would say >15 is a problem with potential pooling. Not sure how to apply that to your test result. on the high end of the lab range is probably not good in this care no matter the test.


I suffer from strong fatigue, and mental brain fog etc struggle to work or do complex brain calculations. So It's definitely a problem. I've been hoping over the past year I'd be able to bring it down etc but it's not budging :/
 
The only thing that lowers RT3 is to add T3 the downside it's a lot of trial and error and titration of the dose and yes it can be twice per day.
 
When you say low doses what did you end up taking? Also how often did you dose? I've heard T3 has a short half-life and sometimes needs dosing multiple times a day.
10 mcg first thing every morning. A couple times I tried adding 5 mcg midday, but didn't notice any difference.

I suffer from strong fatigue, and mental brain fog etc struggle to work or do complex brain calculations. So It's definitely a problem. I've been hoping over the past year I'd be able to bring it down etc but it's not budging :/
Aside from the T3, adding more protein at breakfast has been helpful to me in reducing brain fog. But my serum protein was usually at the bottom of the range, so your mileage may vary.
 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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