*Rookie estrogen blocker questions*

I'll keep this short but hopefully informative.

I am a disgusting 360 lbs. I was in a bad accident years ago, multiple brain surgeries, obviously laid up for a while.
About 6 months ago, I started T injections of 200mcg spread out into 4 shots in a 2 week period. I was massively fatigued, sleeping 14 hours a day. No exercise, no energy. At this point, I got my estrogen checked. It was triple of what it should have been (by LabCore stamdards). And so begins 0.25 anasterazole with each injection.
Still no change for about a month. Then I finally forced myself to be active, and things have been slowly improving. But I'm still not impressed with my energy level. As of a few days ago, I fired up my Google machine and I see some bro-science about stopping the estrogen blocker. And I'm absolutely clueless about how to proceed.

I haven't lost much weight this entire time, and my T therapy journey has been quite a disappointment.

Any thoughts or suggestions would be very helpful.
Total victory to all my newfound brothers.
 
You may need to increase injections to EOD or daily to lower estrogen, daily you would aromatase less and estrogen will be lower. High estrogen makes me sleepy all day and energy is low.

You don't even mention where your Total T, Free T and estrogen sit on your current protocol, it will be difficult to help without this very important info. You really need to post up some labs, SHBG included.

It sounds like you're using the wrong estrogen testing, the LC/MS/MS method is the correct test. The standard test can overstate your levels if inflammation is high, which is common in obese people.

I inject EOD because I'm 33% BF (73 lbs overweight) and therefore estrogen will be higher in obese males. My estrogen was much higher injecting larger does twice weekly, v.s EOD.
 
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Welcome to Excelmale. We're glad you've joined us and hope your journey is a success.

Let's not rush directly into your specific question. A TRT protocol has to be fired holistically. What were your pre-TRT lab values? Total and free testosterone, estradiol/sensitive (LC,MS/MS), SHBG, CBC, CMP, LH, FSH, thyroid values, prolactin, and PSA. Post them all with the range.

Then, what did you and your doctor discuss in regard to a protocol design? How long did you follow that protocol before testing and what are your most recent lab results? It's a long road you're walking, but we all want you to achieve your goals.

The more information you can provide the more we can offer for your consideration.
 
With my friends above it would be very poor advice if some one said do x and Y without seeing any of your lab results. Post as attachments, screenshots, or type it out with the lab ranges.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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