The is the longest term study of testosterone therapy (TTh) I've seen. The full text of the study is available online. The summary says:
"Our findings demonstrate that in subpopulations of men in different weight categories at baseline, long-term TTh produced significant weight loss while untreated men in each subgroup (controls) had increased weight, WC, and BMI. We wish to point out that, in this study, the majority of hypogonadal men were obese. There were 77 deaths in the untreated groups and 23 deaths in the T-groups. No patient dropped out. Medication adherence to T was 100 per cent as all injections were administered in the doctor’s office and documented. We therefore suggest that adequate long-term TTh in hypogonadal overweight and obese men produces progressive and sustained, clinically meaningful weight loss and this Th may reduce mortality and incidence of major adverse cardiovascular events."
"Our findings demonstrate that in subpopulations of men in different weight categories at baseline, long-term TTh produced significant weight loss while untreated men in each subgroup (controls) had increased weight, WC, and BMI. We wish to point out that, in this study, the majority of hypogonadal men were obese. There were 77 deaths in the untreated groups and 23 deaths in the T-groups. No patient dropped out. Medication adherence to T was 100 per cent as all injections were administered in the doctor’s office and documented. We therefore suggest that adequate long-term TTh in hypogonadal overweight and obese men produces progressive and sustained, clinically meaningful weight loss and this Th may reduce mortality and incidence of major adverse cardiovascular events."
