cohort study

This study result is unexpected. Glucosamine supplementation reduced all cause mortality by 15% in a large observational study. "This population-based prospective cohort study included 495 077 women and men (mean (SD) age, 56.6 (8.1) years) from the UK Biobank study. Participants were recruited...

The occurence of fractures in an elderly population is a significant concern, so this study looked at the relation between the number of fractures and hormone levels, including testosterone. It found fractures were higher at both low and high levels of endogenous testosterone: "Analysis of...

More evidence that TRT is safe for men after surgery for prostate cancer in this study: "850 patients underwent radical prostatectomy by a single surgeon. All patients had preoperative testosterone and sex hormone binding globulin levels drawn; free testosterone was calculated prospectively.152...

Another study looked at American dietary habits to try to determine their effect on testosterone deficiency. The study found two significant factors: Vitamin A, which I have not seen in previous studies, and the combination of protein, fat, and phosphorus, which sounds to me like a proxy for...

Another study shows testosterone levels have declined. Unfortunately, the abstract does not say the amount of the decline. Also note that the study says 20% of young men have low testosterone. Here is the complete abstract: "Testosterone deficiency has a prevalence of 20% among adolescent and...

The is the longest term study of testosterone therapy (TTh) I've seen. The full text of the study is available online. The summary says: "Our findings demonstrate that in subpopulations of men in different weight categories at baseline, long-term TTh produced significant weight loss while...

The study described in this article found a lower risk of prostate cancer in men on testosterone therapy. "We conducted a study assess whether testosterone therapy (TT) alters prostate cancer risk using a large US commercial insurance research database. From the HealthCore Integrated Research...

Another study finds increased risk of kidney stones. The abstract says: We conducted a population-based matched cohort study utilizing data sourced from the Military Health System Data Repository (a large military-based database that includes beneficiaries of the TRICARE program). This included...

I don't understand the mechanism at work here, but the design of the study seems sound. To reduce the risk of kidney stones, stay well hydrated and don't use calcium supplements. This news article cites the study: "We conducted a population-based matched cohort study utilizing data sourced from...

A new study tracked men on TRT for five years and tracked cardiovascular events. It found about a 20% increased risk in men on TRT, mostly during the first two years. The abstract says: "Using the UK Clinical Practice Research Datalink (CPRD), we formed a cohort of men aged 45 years or older...

This study is getting a lot of attention in the press today. It used "Mendelian randomization." Basically, some genetic variants cause men to have lower testosterone levels and the study compared the rates of heart disease between men with and without these genetic variations. The study used...