Relationship between testosterone and klotho

[Nelson Vergel]

My first time reading about klotho.

The relationship between klotho, testosterone, and sexual health parameters among US adult men - Journal of Endocrinological Investigation

Background Klotho is a pleotropic hormone involved in a multitude of biological processes necessary for healthy aging, and affords protection from adverse events such as cardiovascular disease, inflammation, and various cancers. Emerging evidence suggests that klotho is also an important...

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[Nelson Vergel]

Klotho is a protein that is encoded by the KL gene and exists in three subfamilies: α-klotho, β-klotho, and γ-klotho. α-klotho is highly expressed in the brain, liver, and kidney, and activates FGF23. β-klotho is predominantly expressed in the liver and activates FGF19 and FGF21. γ-klotho is expressed in the skin. Klotho can exist in a membrane-bound form or a soluble, circulating form. Proteases can convert the membrane-bound form into the circulating form. Klotho is a transmembrane protein that provides some control over the sensitivity of the organism to insulin and appears to be involved in aging. Its discovery was documented in 1997 by Makoto Kuro-o et al. Klotho is an anti-aging protein with pleiotropic actions that exerts organ protection. Several lines of evidence support the notion that Klotho functions as a human aging-suppression molecule. Polymorphisms of KLOTHO are correlated with life span, coronary artery disease, atherosclerosis, and osteoporosis in humans. Klotho is also associated with severe calcinosis and stroke. Soluble klotho is the main functional form in the circulation and is detected in the blood, urine, and cerebrospinal fluid.

Sources
[1] Klotho Klotho (biology) - Wikipedia
[2] Klotho, Aging, and the Failing Kidney - Frontiers Klotho, Aging, and the Failing Kidney
[3] Biological Role of Anti-aging Protein Klotho - PMC - NCBI Biological Role of Anti-aging Protein Klotho
[4] Molecular Basis of Klotho: From Gene to Function in Aging - PMC - NCBI Molecular Basis of Klotho: From Gene to Function in Aging
[5] The Klotho proteins in health and disease | Nature Reviews Nephrology The Klotho proteins in health and disease - Nature Reviews Nephrology
[6] The role of klotho in chronic kidney disease | BMC Nephrology | Full Text The role of klotho in chronic kidney disease - BMC Nephrology

By Perplexity at https://www.perplexity.ai/?s=m&uuid=aa99cc2f-6983-4ea9-b9fc-5381707bb814

 

[Nelson Vergel]

Klotho is a protein that has been shown to have several health benefits. Here are some of the benefits of Klotho:

- Increases nitric oxide production, mediates anti-inflammatory actions, and maintains calcium balance in the vasculature[1].
- Reduces inflammation and oxidative stress when introduced into the bloodstream[2].
- Suppresses oxidative stress and senescence-associated inflammation, functioning as both an anti-aging and organ-protective protein[3].
- Improves cardiac pathologies and overall vascular health[4].
- Maintains the balance between reactive oxygen species (ROS) and antioxidant agents[4].
- Protects against numerous pathologies including cataract, organ fibrosis, sarcopenia, impaired wound repair, gait disturbances, skin aging, rheumatoid arthritis, and even cancer[4].
- Improves cognition and muscle regeneration[5][6].

Klotho is essential for a long, healthy life, and low Klotho levels have been associated with age-related disorders such as cardiovascular disease, diabetes, sarcopenia, and cognitive decline in both humans and laboratory animals[5].

Sources
[1] Klotho: An Elephant in Aging Research - PMC - NCBI Klotho: An Elephant in Aging Research
[2] New Insights Into The Anti-Aging Properties Of Klotho - Forbes New Insights Into The Anti-Aging Properties Of Klotho
[3] Klotho: The protein that could extend your healthspan and lifespan - Longevity.Technology Klotho: The protein that could extend your healthspan and lifespan
[4] Klotho: The Longevity Factor - IBL America Online Store Klotho: The Longevity Factor
[5] Klotho protein: anti-aging benefits and improved cognition. Klotho protein: anti-aging benefits and improved cognition.
[6] Factors That Increase Klotho (Protein) + Gene Associations - SelfHacked Factors That Increase Klotho (Protein) + Gene Associations - SelfHacked

 

[Nelson Vergel]

There are several ways to increase Klotho levels in the body, including:

1. Exercise: Chronic exercise training for a minimum of 12 weeks has been shown to significantly increase Klotho levels in the body, regardless of the individual's health condition or the type of exercise intervention. Resistance training and aerobic training have been found to be particularly effective in increasing Klotho levels[1].

2. Diet: Certain nutrients have been found to predict higher serum Klotho levels in adults aged 20-87 years. These include dietary fibers, phosphorus, and potassium[5].

3. Activated charcoal: Activated charcoal has been found to increase the production of Klotho[3].

4. Probiotics: Probiotics have also been found to increase the production of Klotho[3].

5. Statins: Statins have been found to increase the production of Klotho[3].

6. KlothoBios therapy: KlothoBios is working on a therapy for improving Klotho levels. They have shown they can increase levels of Klotho through proprietary bioelectric stimulation signals and filed patents for controlling or increasing Klotho levels[3].

7. Transgenic insertion of the klotho gene: A transgenic insertion of the klotho gene has been developed to raise Klotho levels[4].

It is important to note that more research is needed to fully understand the effects of these methods on Klotho levels and overall health.

Sources
[1] A systematic review and meta-analysis demonstrating ... A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine - Scientific Reports
[2] Klotho: An Elephant in Aging Research - PMC - NCBI Klotho: An Elephant in Aging Research
[3] How can you measure and increase your Klotho protein levels? How can you measure and increase your Klotho protein levels?
[4] Improving Brain Creatine Uptake by Klotho Protein ... Improving Brain Creatine Uptake by Klotho Protein Stimulation: Can Diet Hit the Big Time?
[5] Individual nutrients and serum klotho levels in adults aged ... https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.3310
[6] Orally-active, clinically-translatable senolytics restore α- ... https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00096-2/fulltext