DHEA Levels Are Associated With Lower Risk of Type II Diabetes

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A recent study published in Diabetologia investigated the impact of DHEA, DHEAS, androstenedione, and the ratio of DHEAS to DHEA on type II diabetes.

Data from 5,189 men and women were gathered. After adjusting for age, sex, cohort, fasting status, fasting glucose, insulin, and BMI, "both serum DHEA and serum DHEAS levels were inversely associated with risk of type II diabetes in the total population." Further analysis showed that androstenedione was not associated with risk of type II diabetes, not what the DHEAS to DHEA ratio.

https://link.springer.com/article/10.1007/s00125-016-4136-8
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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