Re-evaluating the role of Free Testosterone and SHBG

[madman]

Thread 'Importance of free testosterone measurement in assesssing androgen disorders'

Jun 15, 2025

As usual Nelson's house is where it's at!

Importance of free testosterone measurement in assessing androgen disorders

Thursday, March 27, 2025 at 1:00 PM Eastern Daylight Time.

event.on24.com

Testosterone imbalances affect men, women, and children differently. In males, testosterone deficiency (hypogonadism) can lead to low libido, fatigue, and muscle loss, while excess may contribute to aggression and cardiovascular risks. In females, testosterone excess (hyperandrogenism), often associated with polycystic ovary syndrome (PCOS) or adrenal disorders, can cause excess hair growth, weight gain, and menstrual irregularities. In children...

• madman
• hypogonadism; free t; accuracy assays/diagnosis
• Replies: 24
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'Dr. Shalender Bhasin: Optimizing the Diagnosis and Treatment of Hypogonadism 2025'

Oct 7, 2025

Nelson's house u heard it here first!

Dr. Shalender Bhasin!

* over the past 4 decades he has become a global leader in the biology of androgens, sarcopenia and aging related functional decline, his research has shaped clinical guidelines, its informed public health policy particularly around testosterone therapy, anabolic interventions and then the development of function promoting therapies




Pay attention to 25:40-34:36 of the presentation where he explains the importance of measuring free testosterone using a standardized Equilibrium Dialysis method!

Explains the...

• madman
• hypogonadism; diagnosis/treatment; trt
• Replies: 31
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'Free T vs Total T - Cutoffs and Symptoms - Where Are the Data?'

Oct 13, 2025

25th Annual Fall Scientific Meeting of SMSNA!

Grapevine, Texas.




1:14:05-1:29:40

Recommendatios for Dealing with Free T

Concept of Total Hormonal Load

Keep in mind all those men with normal TT and high SHBG!

Reasonable, Evidence-based Recommendation for Managing T

• madman
• cutoff/symptoms hypogonadism; testosterone; ft vs tt
• Replies: 13
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'How to Avoid a Mad "T" Party: Evaluation and Management of Male Hypogonadism'

Nov 2, 2025

One of the big boys in the field!

Dr. Anawalt!

Pay attention to the Q&A (43:20-56:30) especially when it comes to testing free testosterone!




43:20-46:27 - How do we assess for free testosterone?

* There's a direct antibody assay (IA) that measures free testosterone it is notoriously inaccurate and notoriously underestimates the true free testosterone as much as 30% so you should never use that but it is cheap, its easy, its quick so all labs offer it

• madman
• hypogonadism; t-therapy; diagnosis; health
• Replies: 15
• Forum: Testosterone and Men's Health Articles

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[madman]

Thread 'The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)'

Nov 8, 2025

* With CLASH-free, we will improve the clinical applicability of free steroid hormone concentrations in patients with specific conditions by using state-of-the-art methods.


* Formulas to estimate free steroid hormone concentrations are used instead, but their applicability in many clinical conditions is questionable, so is the correctness of therapeutic actions based on these results.


* We will improve current formulas to better estimate free hormone levels.

Research Portal - The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)

Steroid hormones such as testosterone or vitamin D are vital forhuman physiology. In circulation, steroid hormones bind to specificbinding proteins and albumin, with only a small fraction circulatingfreely. The ‘free hormone hypothesis’ suggests that this free fractionis responsible for...

research.kuleuven.be

...

• madman
• equilibrium dialysis; cft hypogonadism; free testosterone; shbg
• Replies: 2
• Forum: Testosterone and Men's Health Articles