Question about SHBG, Nelson's video vs different medical site

[chasedat]

I was watching the video here,

https://www.excelmale.com/?s=16-Practical-Tips-for-Testosterone-Replacement-Therapy

Where Nelson was talking about SHBG and how it holds on to testosterone and doesn't let the body use it. Makes sense.

Here's where I'm confused. He had mentioned having a higher SHBG caused by obesity, or other reasons would in turn raise the SHBG and cause the protein to hold on to more testosterone to not be used.

on this website,

http://emedicine.medscape.com/article/122824-workup

It says the opposite:

Obesity decreases the sex hormone–binding globulin (SHBG) level and therefore decreases the total testosterone level.

That suggests that with a lower SHBG, more testosterone is being held and not utilized by the body.

Does anyone have some input on which it is? Does higher or lower SHBG hold more testosterone hostage?

Thanks for any info

 

[Vince Carter]

The higher SHBG leads to LOWER, Free T...it doesn't effect Total T. A lower SHBG leaves more Free or bioavailable T, which is the T that your body can use. Obesity aside I don't think you're second reference is correct. Free T is (ideally) 2.5-3% (or higher) of the Total, which means the rest, ~97% is bound and unusable in the body.

 

[Vince]

I thought this post was good. Low SHBG ! Good or bad? https://www.excelmale.com/forum/showthread.php?3085-Low-SHBG-!-Good-or-bad

 

[chasedat]

Good stuff thanks guys

 

[johndoesmith]

The higher SHBG leads to LOWER, Free T...it doesn't effect Total T. A lower SHBG leaves more Free or bioavailable T, which is the T that your body can use. Obesity aside I don't think you're second reference is correct. Free T is (ideally) 2.5-3% (or higher) of the Total, which means the rest, ~97% is bound and unusable in the body.

From what I understand, higher SHBG will "inflate" total testosterone levels. Basically because it holds more of it. Is this not true?