Question About Dht antiestrogenic effect.

[Damian]

How DHT blocking access of estrogen to its receptor? 1) DHT connects directly to the estrogen receptor and blocks Is DHT blocking a receptor on the same principle as clomid, or DHT connects with its receptor and this results in a further way weakens Join estradiol to its receptor.

 

[kaufenpreis]

One important function of DHT in the body that does not get much discussion is its antagonism of estrogen. Some men that take Proscar learn this the hard way—by developing a case of gynecomastia. By reducing DHT's protection against estrogen in the body, these men have fallen victim to its most dreaded ramification-bitch tits.

How does DHT protect against estrogen? There are at least three ways that this likely occurs. First of all, DHT directly inhibits estrogens activity on tissues. It either does this by acting as a competitive antagonist to the estrogen receptor or by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding.

Second of all, DHT and its metabolites have been shown to directly block the production of estrogens from androgens by inhibiting the activity of the aromatase enzyme. The studies done in breast tissue showed that DHT, androsterone, and 5alpha-androstandione are potent inhibitors of the formation of estrone from androstenedione. 5alpha-androstandione was shown to be the most potent, while androsterone was the least.