PT 141 diminishing effect on erections?

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stx359

Active Member
Has anyone experienced diminishing effect from Pt 141 over time? It worked extremely well for me the first few uses but got less and less over time. The side effects, nausea and muscle soreness, did not decrease. The vial, which I keep refrigerated, is a couple months old. Could it degrade over that time?
 
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sammmy

Active Member
Have you tried Cialis? It is way more predictable, with possibly fewer side effects, and is not expensive from an indian online pharmacy.

Pt-141 is not popular simply because it is not better than standard viagra/cialis.

They all affect erection only, no effect on libido, orgasm, or ejaculation. People often claim pt-141 increases libido but it just make spontaneous erection more probable, just like Cialis, and people interpret that as 'I'm more horny than usual".
 

Cataceous

Super Moderator
In my experience PT-141 does lose potency over time after hydration, and I wouldn't even bother using it once it gets close to two months old.
 

DorianGray

Active Member
Not knowing any better, I stored my PT-141 unrefrigerated for over a month. It had the same effect, at the same dose from the first drop to the last. Potency may have diminished but not enough to produce any noticeable lessened effect. It was cool and out of light but not refrig level.
 

stx359

Active Member
Have you tried Cialis? It is way more predictable, with possibly fewer side effects, and is not expensive from an indian online pharmacy.

Pt-141 is not popular simply because it is not better than standard viagra/cialis.

They all affect erection only, no effect on libido, orgasm, or ejaculation. People often claim pt-141 increases libido but it just make spontaneous erection more probable, just like Cialis, and people interpret that as 'I'm more horny than usual".

I am afraid I have to politely disagree with you. PDE-5 inhibitors move blood via their effect on NO, PT-141 exerts an entirely different effect on the melanocortin system. I use cialis as part of my daily NO stack. My initial experience with PT-141 was that the effect was dramatic and synergistic with cialis without the threat of priapism. From a mechanistic perspective PT 141 is incredibly interesting.
 

stx359

Active Member
In my experience PT-141 does lose potency over time after hydration, and I wouldn't even bother using it once it gets close to two months old.
My vial is close to three months so perhaps that is the issue. In any case the initial effect was encouraging enough to try another vial.

May I ask if you had any issue with side effects? I experience a little flushing and a hint of nausea shortly after injection. Both are mild and transitory. I do experience a little soreness/fatigue which I do not like but it is not a deal breaker. I still have not figured out timing. In my case it reaches peak effectiveness anywhere from 4-8 hours after administration. Would love to hear others experience.
 

Cataceous

Super Moderator
My vial is close to three months so perhaps that is the issue. In any case the initial effect was encouraging enough to try another vial.

May I ask if you had any issue with side effects? I experience a little flushing and a hint of nausea shortly after injection. Both are mild and transitory. I do experience a little soreness/fatigue which I do not like but it is not a deal breaker. I still have not figured out timing. In my case it reaches peak effectiveness anywhere from 4-8 hours after administration. Would love to hear others experience.
I get some slight flushing. I also found 4-8 hours in advance to be good. The overnight effect is what's really dramatic. I'm no longer using it because the results were kind of inconsistent, and it may have caused problems on some of the days after using it.
 

captain

Active Member
Pt-141 from compounding pharm comes ready to use. The ones I have got had about a 3 week to use by date. Says to keep it frozen. Effect is dramatic but hard to time it for use.
 

Guided_by_Voices

Active Member
I have used a vial over 4-6 months and I did not notice any reduction in potency or affect. IMO however, the doses people usually use are way too high and that might be why some people experience a reduction in affect. I never use over over 500 mcg at a time. That said, I respond very well to very small doses of most things. I agree that the overnight affect is the strongest. Sleep seems to be synergistic with it so it may be the sleep more than the timing.
 

Jason Sypolt

Administrator
How often do you use it? Melanocortin receptors can become desensitized to the libido enhancing effects in a lot of people if it is used more than 1-2 times per week. A 2-3 week break should help.

Shelf life is going to depend on how the peptide was made. Some PT-141 products work for 30-45 days. There are others which have a 6-month shelf life and don’t require any refrigeration.
 

DorianGray

Active Member
I don't know about diminishing effectiveness if used over time but I certainly feel it could have some addictive influence. I limit it to once per week at most.
 

stx359

Active Member
How often do you use it? Melanocortin receptors can become desensitized to the libido enhancing effects in a lot of people if it is used more than 1-2 times per week. A 2-3 week break should help.

Shelf life is going to depend on how the peptide was made. Some PT-141 products work for 30-45 days. There are others which have a 6-month shelf life and don’t require any refrigeration.
I never use more than once a week.

This vial came mixed which I was not happy about. Its impossible to know how long since it had been reconstituted or how conscientiously it was handled. It did come in a box with cold packs.
 

Jason Sypolt

Administrator
I never use more than once a week.

This vial came mixed which I was not happy about. Its impossible to know how long since it had been reconstituted or how conscientiously it was handled. It did come in a box with cold packs.
I’ve noticed that a lot of the smaller compounding pharmacies are doing that. Maybe they don’t have the equipment to lyophilize the product, or it would increase the expense.

I am not too familiar with the products that ship ready to use so I can’t give you much info on them unfortunately. I would call the pharmacy that dispensed then and ask to speak to a pharmacist. They are required to answer any questions and concerns that you have and the answers would come directly from the source.
 

Guided_by_Voices

Active Member
@DorianGray , I have taken it before bed and had no problem sleeping , however that might have been an issue if I had taken the larger doses most use. Dr Hertoghe has a video where he IIRC recommends starting with 100mcg per day and working up to 500mcg. That is 1/10th to 1/20th of what most people seem to use.
 

DorianGray

Active Member
@DorianGray , I have taken it before bed and had no problem sleeping , however that might have been an issue if I had taken the larger doses most use. Dr Hertoghe has a video where he IIRC recommends starting with 100mcg per day and working up to 500mcg. That is 1/10th to 1/20th of what most people seem to use.

Good to know. Perhaps the others are using a lower concentration. I currently have been using Tailor Made's 2000mcg/2000mcg/ml. I find the prescribed dose of .1ml to be more than adequate. I think that calculates to 200mcg.

I couldn't find the link on Hertoghe's website. If you have it, please post. Thanks.
 
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