Problem reconstituting Puretrig HCG...

[DaveK22]

I been reconstituting HCG for years & I have never experienced this problem before.

I ordered the Puretrig brand from reliablerx. Last month I went to fill my BAC water into vial & it was so pressurized I could barely get the water in.

So this month I took the tip off my large 5ml filling syringe to insert needle to allow for "equalization" as the needle tip was open & removed from syringe.

I went to fill as normal...and shocked that the back pressure was still there. I forced plunger down & when I pulled needle out...it squirted out the stopper due to the pressure. Like I said...not a newbie to this at all. WTH is going on?

 

[bixt]

I no longer post here, but just want to point out two things (because one is potentially dangerous) from experience with this brand:

1. The water that comes with Puretrig is NOT bac water but saline. Meaning its not suitable for multiuse, only a single 5000IU shot. Get or make bac water if doing multi use. If you were not aware of this, you could get a serious abscess or worse due to vial contamination. Fridges harbour bacteria.

2. The stopper is extra thick rubber and blunts my needle, so as a matter of procedure I always use a sterilised pliers to pull the top foil and then remove the rubber stopper completely. I then inject 1ML bac water, swirl the vial and then draw up 0.1ml x 10 using insulin all in ones, being careful not to touch the needle to the glass. Do this on a completely sterilised glass table to avoid contamination and double container the resulting syringes to keep fridge contamination out. This method of course also solves your pressure problem at the same time.

 

[DaveK22]

I no longer post here, but just want to point out two things (because one is potentially dangerous) from experience with this brand:

1. The water that comes with Puretrig is NOT bac water but saline. Meaning its not suitable for multiuse, only a single 5000IU shot. Get or make bac water if doing multi use. If you were not aware of this, you could get a serious abscess or worse due to vial contamination. Fridges harbour bacteria.

2. The stopper is extra thick rubber and blunts my needle, so as a matter of procedure I always use a sterilised pliers to pull the top foil and then remove the rubber stopper completely. I then inject 1ML bac water, swirl the vial and then draw up 0.1ml x 10 using insulin all in ones, being careful not to touch the needle to the glass. Do this on a completely sterilised glass table to avoid contamination and double container the resulting syringes to keep fridge contamination out. This method of course also solves your pressure problem at the same time.

I am fully aware on #1…I always use my own BAC water.

#2 is a work around I guess but doesnt explain why other brands (using my same method) never had this problem.

 

[Wolverine]

I am currently using Puretrig also from Reliable and do not have that problem. Maybe a one off?

 

[DaveK22]

I am currently using Puretrig also from Reliable and do not have that problem. Maybe a one off?

I ordered 6 from same source and the first 2 did the same thing.
Like previously stated, I bought from Reliable for years & never had this issue before with other brands.

 

[Deleted member 16042]

I have noticed more pressure in some vials, and in any case release the pressure in a couple ways.

First I use a large enough 3ml syringe with luer tip and mix 2.5ml of bac water to 5000iu. Keeping the vial upright, if there is pressure during injecting the water, I just do a little back and forth with the plunger which allows as much as 3ml of air air back into the syringe. Water flows down, air comes up.

Second, I detach the syringe from the tip with the needle still in the vial so any extra air can escape. Of course be sure the needle tip is not down in the fluid doing this

 

[Deleted member 16042]

I no longer post here,

Izzat right? Funny.

 

[DaveK22]

@Blackhawk like I stated in my first post, I removed my "luer" type tip from my 5 ml syringe...used alcohol on needle and pushed it it. I was 99% sure that what ever pressure was in the vial would now be equalized. It was not at all.

Thanks for your suggestions on the back & forth method...I have about a month before my next fill job. I'm also thinking about pushing tip only in...then while it's still in the stopper...screw the syringe back on & pull plunger out maybe forcing a decompression by "sucking" pressure out?

Can't believe I'm even having this discussion lol

 

[Deleted member 16042]

@Blackhawk like I stated in my first post, I removed my "luer" type tip from my 5 ml syringe...used alcohol on needle and pushed it it. I was 99% sure that what ever pressure was in the vial would now be equalized. It was not at all.

Sorry I didn't understand your post at first reading. Sounds like the needle was plugged. No idea why.

 

[DaveK22]

Sorry I didn't understand your post at first reading. Sounds like the needle was plugged. No idea why.

Wow…never thought of that! Its plausible that a tiny rubber “core” got stuck in needle end & never allowed for the depressurization.

Next time I will insert fill syringe needle with it on syringe, push a little bit on plunger, then unscrew. Then if there was a blockage, it should be clear after a little “pump”.

Thx for the suggestion

 

[BadassBlues]

"Wow…never thought of that! Its plausible that a tiny rubber “core” got stuck in needle end & never allowed for the depressurization."

It's obvious you are no noob. I can't imagine that kind of pressure and not being able to dissipate it. I have had to depressurize a few vials of various substances over the years, I will usually just use a 3 ml transfer syringe and suck some air out. Sometimes I'll remove the needle from the syringe and just let it vent itself out. I have had a few instances of having a blowback and getting stabbed.

I think you may have nailed it, the needle may have got plugged somehow.

I buy from Reliable, but have never used that product. Try a new syringe and let us know. If there is a problem, regardless of how random, this may be a product to avoid.

 

[Marchickney]

I no longer post here, but just want to point out two things (because one is potentially dangerous) from experience with this brand:

1. The water that comes with Puretrig is NOT bac water but saline. Meaning its not suitable for multiuse, only a single 5000IU shot. Get or make bac water if doing multi use. If you were not aware of this, you could get a serious abscess or worse due to vial contamination. Fridges harbour bacteria.

2. The stopper is extra thick rubber and blunts my needle, so as a matter of procedure I always use a sterilised pliers to pull the top foil and then remove the rubber stopper completely. I then inject 1ML bac water, swirl the vial and then draw up 0.1ml x 10 using insulin all in ones, being careful not to touch the needle to the glass. Do this on a completely sterilised glass table to avoid contamination and double container the resulting syringes to keep fridge contamination out. This method of course also solves your pressure problem at the same time.

2. Same experience with thick top - i am ordering empty vials and using a filtered "draw" needle to transfer over whole amount to a better vial to store/draw from. Spending 15 miins setting up months worth at start of new vial better than Pain of blunt needles EOD lol.

 

[Wilson7]

I use Pregnyl. Take a 10 cc syringe and 23 - 25 g 1", generally the vial to be reconstituted has some over pressure, I'll draw about 5 cc of air from the HCG vial and create a vacuum, then fill the syringe with 10 cc of BAC water (MC makes a good point regarding saline vs BAC) for multi dose. Be careful to hold the plunger and then slowly add the water to the vial containing the HCG, do not foam the solution for any peptide, after adding about 5 cc there will be more back pressure, just draw back on the syringe and remove more air, then finish pushing the remaining 5 cc of BAC in. Before removing the needle, let the pressure equalize. Gently rock the vial until dissolved, do not shake.

 

[Marchickney]

I been reconstituting HCG for years & I have never experienced this problem before.

I ordered the Puretrig brand from reliablerx. Last month I went to fill my BAC water into vial & it was so pressurized I could barely get the water in.

So this month I took the tip off my large 5ml filling syringe to insert needle to allow for "equalization" as the needle tip was open & removed from syringe.

I went to fill as normal...and shocked that the back pressure was still there. I forced plunger down & when I pulled needle out...it squirted out the stopper due to the pressure. Like I said...not a newbie to this at all. WTH is going on?

View attachment 38957

I have taken a couple of pics of the rubber stopper necks of a Puretrig vs a Gen-X bottle. The Puretrig is definitely a wee bit narrower, never had any issues with other brand. However, found I use a window or light source and spin the bottle around so filler gap lines up with light and carefully insert needle more likely to get it lined than just blindly popping it in the middle looking at top which you get away with on the wider necks. Hope this helps others and stops us all injecting rubber bungs into ourselves haha....

 

[Vince]

I have zycg form reliable. I used a 29 g half inch syringe to fill the vial. I put 3,000 IU of bac in the vial. So I inject 150 IU for 500 IU of HCG. It is a little bit difficult mixing with the small syringe but it does work.

 

[DaveK22]

Final post on this thread...turns out the problem all along was the large filling syringes (3 pack) I ordered off Ebay. Lesson learned there I guess!

After using the syringes to reconstitute a peptide, and then had the same "pressure issue" that I had with filling my HCG, I made the connection and switched to an insulin syringe to finishing filling my BAC...with no issues.

They appear to be decent quality but something definitely funky is wrong with them...they are now all going into the sharps container lol