Pregnenolone – By Gene Devine


Table of Contents


Pregnenolone - Why You Need It


Pregnenolone is a hormone that many Doctors and men are not familiar with or understand its role in the CHOL pathways but it’s critically important to our health as it is a "precursor hormone" to all other hormones in our body. Restoring Pregnenolone to optimal levels is important but seems to get the least attention by Doctors. Remember, the testes are the single largest producer of the hormone Pregnenolone. Pregnenolone is important for proper mental functioning and is the precursor to all of the steroid hormones found in the three CHOL pathways such as DHEA, testosterone, DHT, estrogen, cortisol...

So What are The Benefits of Pregnenolone?


In our bodies Pregnenolone is synthesized from cholesterol (CHOL) via the P450scc enzyme. This critical hormone performs many functions in a man’s body, including:

  • Promotes healthy brain function and protects against dementia and Alzheimer's disease. Many
    men state feeling good when they start supplementing Pregnenolone.

  • It can also prevent age related diseases and support the Central Nervous System (CNS).

  • Boosts the immune system and increases energy production.

  • Protects against coronary disease and improves heart health and can lower cholesterol levels.

  • Enhances mood and relieves depression. Many men state their mood betters when they start

  • supplementation.

  • Relieves arthritis pain!

  • Fights the effects of fatigue and stress.


The optimal serum levels for Pregnenolone is 180 ng/dl for men. Pregnenolone can be purchased over the counter in a pill form (micronized slow release is the best for oral pills) or sublingual form in addition to transdermal applications. A typical dose is 50 to 200 mg daily best taken in the morning on an empty stomach (transdermal applied in the morning as well).
Pregnenolone is considered safe and because it converts to DHEA which supports all three metabolic pathways. The labs for testing Pregnenolone serum levels are wildly inaccurate and expensive so testing for serum levels is really no more than an estimate.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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