Has anyone figured out how to reverse the effects of crashing ur e2? It’s been over a year now since I’ve crashed my e2 and the sides have never subsided. Brain fog, head pressure, ringing in ears, irritability, mood swings, zero libido, dry skin, muscle fatigue, heart palpitations, and anxiety. We’ve tried every witch protocol with no changes. Any help would be appreciated.
Permanently crashed my e2
- Thread starter Matt4673
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Systemlord
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Did you confirmed E2 is still crashed?
If your E2 did recover, then, perhaps maybe you’re experiencing something similar to post finasteride syndrome, where DHT is blocked and recovers, yet symptoms remain.
Hey man, sorry to hear that. I'm in a similar boat.
Do you mind sharing in detail as much of the relevant info as possible? Which AI you took, what protocols you've tried, blood/urine test results etc.
My e2 levels returned in 4-6 weeks and actually were a lot higher than it was prior to the AI as I think it rebounded. All of my labs for the last year have been good.
Hey bud my doctor at the time put me on arimidex. The new doctor has tried every which way to combat my sides with no luck. 200mg a week all the way down to 60mg a week daily sub q with zero changes in the sides I listed above.
I am not a Doctor and I don't play one on TV. This helped me.
1st look at everything you are taking, eating, and drinking. After my crash, things like coffee, Pomegranate Juice, Broccoli, and any supplements, shampoo that can or could lower estrogen would make everything worse.
For weeks after my crash and after my E2 levels were back in range anything that can or could lower estrogen would make the symptoms worse. I took a look at everything that I came in contact with and researched the ones that could lower estrogen and cut them out, and that seemed to stop the more serious sides like the 24 hour Anxiety that makes it impossible to live. The other symptoms never went away until I tried external estrogen.
I crashed my estrogen in 2019 to undetectable levels from using AI's, and from then on anything that can or could lower estrogen would make my symptoms worse. Despite having estrogen levels in range or even a little high the symptoms never went away. I tried everything, The more testosterone I took the worse I felt, I tried single doses, to micro doses, you name it. Went to 2 different Endo's, 3 TRT clinics, no-one could help. I saw Coconutz posts and found that write up on reddit (see link below). So I tried Estriol Valerate, 1st in oral form then in injections (did help a little, and why I moved to injections). for injections I was using 2mg am and 2mg pm. I noticed a great improvement in symptoms. I was using EV for approx 60 days, before I hit a wall. I got anxiety from the excess estrogen, and started getting a few other high estrogen signs. Now my estrogen levels are through the roof, or at least they were on 6/6. I stopped EV injections on June 15th, the anxiety has all but gone away, and I restarted Testosterone, last week. So there is something to adding external estrogen, but there is also other things to consider.
One person who also crashed their estrogen, swears by Wellbutrin. Others claimed it made their symptoms worse.
Check out the link below.
Persistent Low E2 symptoms lasting long after crash- Possible Solution or a little relief.
1st look at everything you are taking, eating, and drinking. After my crash, things like coffee, Pomegranate Juice, Broccoli, and any supplements, shampoo that can or could lower estrogen would make everything worse.
For weeks after my crash and after my E2 levels were back in range anything that can or could lower estrogen would make the symptoms worse. I took a look at everything that I came in contact with and researched the ones that could lower estrogen and cut them out, and that seemed to stop the more serious sides like the 24 hour Anxiety that makes it impossible to live. The other symptoms never went away until I tried external estrogen.
I crashed my estrogen in 2019 to undetectable levels from using AI's, and from then on anything that can or could lower estrogen would make my symptoms worse. Despite having estrogen levels in range or even a little high the symptoms never went away. I tried everything, The more testosterone I took the worse I felt, I tried single doses, to micro doses, you name it. Went to 2 different Endo's, 3 TRT clinics, no-one could help. I saw Coconutz posts and found that write up on reddit (see link below). So I tried Estriol Valerate, 1st in oral form then in injections (did help a little, and why I moved to injections). for injections I was using 2mg am and 2mg pm. I noticed a great improvement in symptoms. I was using EV for approx 60 days, before I hit a wall. I got anxiety from the excess estrogen, and started getting a few other high estrogen signs. Now my estrogen levels are through the roof, or at least they were on 6/6. I stopped EV injections on June 15th, the anxiety has all but gone away, and I restarted Testosterone, last week. So there is something to adding external estrogen, but there is also other things to consider.
One person who also crashed their estrogen, swears by Wellbutrin. Others claimed it made their symptoms worse.
Check out the link below.
Persistent Low E2 symptoms lasting long after crash- Possible Solution or a little relief.
If it is any consolation, you're not alone. There's about a dozen people on this forum who reported long term AI induced low e2 symptoms. Hopefully we can eventually figure out how to resolve this. As of now, there have been some positive reports on e2 supplementation (oral e2 and injectable e2). Maybe that's something you wanna try alongside a steady TRT protocol. I have not yet experimented with exogenous e2 but will do so in the future.
There's been some talk about the e2 crash possibly inducing epigenetic changes that rendered estrogen receptors less responsive (so despite normal serum e2 levels you still feel low e2 symptoms). It's the most "logical" conclusion, I suppose. In theory and proven in some studies, such epigenetic changes are reversible. In layman's terms what could help is providing the body with excess levels of e2 to "wake up" estrogen receptors, so to speak. But what could also help is using some natural compounds that have been proved to reverse epigenetic changes in terms of repression of relevant genes. EGCG, curcumin, resveratrol, sulforaphane ... are some examples.
However, it's worth noting that all these symptoms you experience also present in people with various chronic conditions characterized by chronic inflammation. I am right now researching the possibility of e2 deprivation and consequent androgen excess inducing what I proposed here: Aromasin ruined me for good..
Do you perhaps have some labs showing tt, free t, e2, dht, shbg, dhea, thyroid, ferritin, vit D, cholesterol levels (and whatever else you've tested since the crash, maybe folate and b12 levels or whatever else)? I know you said that the labs show ok levels but I am curious.
There's been some talk about the e2 crash possibly inducing epigenetic changes that rendered estrogen receptors less responsive (so despite normal serum e2 levels you still feel low e2 symptoms). It's the most "logical" conclusion, I suppose. In theory and proven in some studies, such epigenetic changes are reversible. In layman's terms what could help is providing the body with excess levels of e2 to "wake up" estrogen receptors, so to speak. But what could also help is using some natural compounds that have been proved to reverse epigenetic changes in terms of repression of relevant genes. EGCG, curcumin, resveratrol, sulforaphane ... are some examples.
However, it's worth noting that all these symptoms you experience also present in people with various chronic conditions characterized by chronic inflammation. I am right now researching the possibility of e2 deprivation and consequent androgen excess inducing what I proposed here: Aromasin ruined me for good..
Do you perhaps have some labs showing tt, free t, e2, dht, shbg, dhea, thyroid, ferritin, vit D, cholesterol levels (and whatever else you've tested since the crash, maybe folate and b12 levels or whatever else)? I know you said that the labs show ok levels but I am curious.
You mentioned a lot of symptoms but what about these:
- gut issues (bloating, excessive burps/farts, stool appearance etc.)?
- dry mouth or eyes?
- ED?
- joints clicking/squeaking and/or aching?
- muscle twitching?
- how does the anxiety present itself physically?
Also - do the symptoms get worse on higher test doses?
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Yes constipation and bloating I have to take digestive pills just to keep me some what regular. Don’t have Ed issues just none existent libido. My joints ache constantly clicking and making irregular sounds. And yes my muscles have weird twitching sometimes more so right after I crash my E2. The anxiety comes out of no where more so like panic attacks. I could be just watching tv zero stress and bam hits me like a train. The higher t does I felt like the anxiety was worse but the lower t doses I feel like my head is more foggy and the head pressure an ringing in my ears is worse the lower I go.
Yes and No, I was taking 15mgs of test twice a week, then I stopped for a while. Now I have found out since then, Got some of my blood tests back, not complete, but so far everything looked fine with the exception of homocysteine, MCH, and estrogen. We all know that my estrogen would be high, but homocysteine, and MCH are elevated. Both suggest b12 deficiency, but more importantly, estrogen lowers homocysteine. Now consider that my e levels are astronomical, one would think that my homocysteine, levels would be super low, but no they are elevated. I wonder how high they would be if I hadn’t been taking estrogen. I am grasping at straws here, but follow the above and it kinda explains why estrogen helps and why I feel better when I add vitamin C. If you also take into account that diets high in protein also raises homocysteine, which I was of course taking in like 400grams of protein per day, add in some alcohol and smoking at times, which all raise homocysteine it starts to make sense that high homocysteine levels may have been the culprit, or that in adding all the external E woke up my receptors. I have been off E since like 9/6, and have added B12 shots and Folic Acid, and am back on TRT at 60mgs every 3 days and feeling a lot better.
Symptoms of B12 Deficiency
Please be aware that this list is by no means exhaustive. Furthermore, symptoms of B12 deficiency are often shared and overlap with many other nutrient deficiencies and separate pathologies, but especially other B vitamins, iron, magnesium and trace minerals. Deficiency symptoms may appear differently in children than adults.Common symptoms of B12/B vitamin deficiency or insufficiency :
- ADHD-like symptoms
- Alzheimer’s-like symptoms/altered memory
- Anemia (megaloblastic, high MCV)
- Angular Cheilitis
- Anxiety and/or sense of impending doom
- Ataxia
- Autism-like symptoms
- Bleeding gums
- Burning sensations
- Brain fog
- Brain “zaps”
- COPD-like symptoms
- Dandruff (excessive)
- Depression
- Depersonalization/derealization
- Dipoplia/double vision/sixth nerve palsy
- Dry skin (excessive)
- Electric shock-like sensations
- Erectile dysfunction
- Fatigue/Chronic Fatigue Syndrome/ME
- Fibromyalgia
- Gait disturbances/alterations
- Glossitis (sore and swollen tongue)
- Heavy/altered menstrual cycles
- High/low pulse rate
- Incontinence
- Insomnia
- Large fiber neuropathy
- Low/no sperm
- Low/no libido
- Memory impairment (Alzheimer's; impaired short term memory, brain fog)
- Migraines
- Mouth Sores
- Multiple Sclerosis symptoms
- Muscle spasms, twitches and cramps
- Muscle soreness unrelated to exercise
- Nail changes (beau’s lines, no half moons, pitting, slow growth, brittle)
- Neuralgia (occipital, trigeminal, etc)
- Numbness
- Optic neuritis
- Paresthesia
- Shortness of breath
- Small fiber neuropathy
- Stabbing/icepick sensations
- Syncope/dizziness
- Tingling/pinprick sensations
- Urinary hesitancy
- Urinary tract infections (reoccurring)
- Vaginal dryness/soreness
- Vertigo/Dizziness
- Weakness, generalized or focal
The same thing happened to me, the main side effect that rings true and alerted me to your specific post on crashed estradiol was the ringing in ears although mine only occurred in the left ear I went back on trt and nearly lost my right ear and more functionality in the left hand side of my body.
I believe crashing e2 for me caused a right hemispheric stroke, the pressure in your head essentially is because you've for lack of a better word got granny arteries and your body can no longer handle high testosterone, I guarantee you if you come off after 3 months the ringing will stop, all the pressure in your head is from the lack of blood flow getting to your brain making you worse, you won't show traditional high red blood cell count or blood pressure but I bet you have a blockage or your arteries just candle handle even the slightest blood thickening I'm having a MRI scan soon I'll let you know how I get on because your case is identical but your not allowing your brain to recover because the trt is minimising blood getting up there can't believe you and your doctor haven't worked that out yet. I also have seen estradiol get back to the sweet spot but symptoms remain essentially we've now unfortunately got an aged brain and lack of receptors in the pre frontal lobe, I bet if you take a t shirt off in the mirror same as me your decolletage goes red white red white quickly suggesting lack of blood flow it's obvious to me, I worked this all out myself, hang in there, by the way if your gonna get out of this essentially you don't want excess estradiol either because it'll increase blood stickiness further perpetuating the issue
silverlining
New Member
Hi all. I am from India, and posting here since I really need your all help.
I am 26 y/o, and a survivor of pfs but had almost recovered to baseline except for some erectile issues/ mild tinnitus/ mild anhedonia before starting my testosterone usage.
Long story short. I used testosterone for gym gains 200mg/week for 8 months then blasted 500mg/week for 3 months and back to 200mg now. My values on 200mg/week were ~3000ng/dl total testosterone and ~157 pg/ml e2. Had no issues whatsoever in these values even on 500mg/week dosages. In June 2026 I starting facing mild anxiety issues at times during high stress situations (I am a lawyer) thinking that the anxiety was from high e2, I started popping 0.25 anastrazole here and there guessing upon my symptoms. In total the whole of june i must have comsumed 4-5 times anastrazole at 0.25 mg dosage and the last dose somewhere in the last week of june was 0.5 mg dose. At the point i didnt face any low e2 symptoms but right in july i started facing high amount of anxiety like everyday. Sleep started worsening. Started with dry skin and started to notice some head pressure in the back of the head along dry insenstive skin penis, and no erections/no morning woods, no libido, low cognition and trouble speaking to people/difficulty coming up with words. Did a blood test at trough levels my tt was ~2000ng/dl and e2 was ~42pg/ml which was severly supressed. The hdl was also elevated at borderline high and
Alanine Aminotransferase (ALT/SGPT) was almost double the reference range 96.5 u/l
I added in hcg and halfed my dosage of test to 100mg/week thinking lowering the dose will maybe bring relief in my symptoms. The hcg at the starting was working penis sensivity and libido. I was dosing 500iu 2-3 times a week. Anxiety started easing up a bit meanwhile but cognition and word recall was still poor. After 20 days or so in August one day all hell broke lose. Felt like I crashed. All of a sudden my joints started paining (knees and elbows), lips became dry, frequent thirst but right after drinking water I would piss everything. Muscle twitches everywhere, extreme sweating even with little physical movement outside, night sweats and in mornings I felt cold (this is abnormal since I never felt like this and Indian weather is very hot at this time of the year), it feels like my body is not able to control its own temp. I am having suicidal thoughts, feel no joy from doing things I loved, simple tasks take twice as long for me to complete, my sleep has also worsened with no sleep somedays. I am not able to convey my own thoughts, stuttering has become worsened, my tinnitus has increased all of a sudden. Seeing all this I increased my dosage back to 200mg/week thinking more test will aromatiser into more e2, hcg has stopped affecting me now, it somehow increases brain fog, Ed and anhedonia. I started consuming e2 valerate pills 2 mg. Did that for 3 days but didn't see any effect.
My fear is that I have permenantly damaged my estrogen receptors or this anastrazole crash has affected my already damaged receptors from finasterside crash. Since at the time of fin crashes I had low e2 as well but that climbed up. i already have damaged AR receptors from pfs but improved substantially over time until now. I don't know what to do? Whether to increase my testosterone dosage or to decrease it or to stop altogether? Or to try dbol? Or to pct with clomid? Please help me out. I can post my blood reports if you want. Docs are don't know nothing in India for male hormones related stuff. I can't live with this anhedonia and depression and in fear that I have permenantly castrated my body. I am just 26. You can check out post history for a detailed post which I had posted but didn't get much response.
I am 26 y/o, and a survivor of pfs but had almost recovered to baseline except for some erectile issues/ mild tinnitus/ mild anhedonia before starting my testosterone usage.
Long story short. I used testosterone for gym gains 200mg/week for 8 months then blasted 500mg/week for 3 months and back to 200mg now. My values on 200mg/week were ~3000ng/dl total testosterone and ~157 pg/ml e2. Had no issues whatsoever in these values even on 500mg/week dosages. In June 2026 I starting facing mild anxiety issues at times during high stress situations (I am a lawyer) thinking that the anxiety was from high e2, I started popping 0.25 anastrazole here and there guessing upon my symptoms. In total the whole of june i must have comsumed 4-5 times anastrazole at 0.25 mg dosage and the last dose somewhere in the last week of june was 0.5 mg dose. At the point i didnt face any low e2 symptoms but right in july i started facing high amount of anxiety like everyday. Sleep started worsening. Started with dry skin and started to notice some head pressure in the back of the head along dry insenstive skin penis, and no erections/no morning woods, no libido, low cognition and trouble speaking to people/difficulty coming up with words. Did a blood test at trough levels my tt was ~2000ng/dl and e2 was ~42pg/ml which was severly supressed. The hdl was also elevated at borderline high and
Alanine Aminotransferase (ALT/SGPT) was almost double the reference range 96.5 u/l
I added in hcg and halfed my dosage of test to 100mg/week thinking lowering the dose will maybe bring relief in my symptoms. The hcg at the starting was working penis sensivity and libido. I was dosing 500iu 2-3 times a week. Anxiety started easing up a bit meanwhile but cognition and word recall was still poor. After 20 days or so in August one day all hell broke lose. Felt like I crashed. All of a sudden my joints started paining (knees and elbows), lips became dry, frequent thirst but right after drinking water I would piss everything. Muscle twitches everywhere, extreme sweating even with little physical movement outside, night sweats and in mornings I felt cold (this is abnormal since I never felt like this and Indian weather is very hot at this time of the year), it feels like my body is not able to control its own temp. I am having suicidal thoughts, feel no joy from doing things I loved, simple tasks take twice as long for me to complete, my sleep has also worsened with no sleep somedays. I am not able to convey my own thoughts, stuttering has become worsened, my tinnitus has increased all of a sudden. Seeing all this I increased my dosage back to 200mg/week thinking more test will aromatiser into more e2, hcg has stopped affecting me now, it somehow increases brain fog, Ed and anhedonia. I started consuming e2 valerate pills 2 mg. Did that for 3 days but didn't see any effect.
My fear is that I have permenantly damaged my estrogen receptors or this anastrazole crash has affected my already damaged receptors from finasterside crash. Since at the time of fin crashes I had low e2 as well but that climbed up. i already have damaged AR receptors from pfs but improved substantially over time until now. I don't know what to do? Whether to increase my testosterone dosage or to decrease it or to stop altogether? Or to try dbol? Or to pct with clomid? Please help me out. I can post my blood reports if you want. Docs are don't know nothing in India for male hormones related stuff. I can't live with this anhedonia and depression and in fear that I have permenantly castrated my body. I am just 26. You can check out post history for a detailed post which I had posted but didn't get much response.
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I see you took masteron along with your testosterone. I would stop taking that immediately and stick with a reasonable dose of testosterone, say 100-120mg/week. I would also keep taking the HCG. Some guys don't do well on testosterone without HCG.
You really need to get labwork done. Sensitive E2, total T, Free T, SHBG. We don't have any idea what your levels are and thus is it difficult to make any judgements about your case
How are you feeling right now?
t_spacemonkey
Well-Known Member
not selling shit, but look into estradiol cypionate and dht enanthate from 5arsociety - at ultra low doses some guys had success
I personally use Estradiol cream. I have to. I just don't make enough estrogen even with pretty high testosterone doses. E2 cream has been an amazing add for me
silverlining
New Member
My estrogen has come back normal after blood tests, but sides are still persisting. The worste of the being insomnia, penis like a dried out raisin, increased tinnitus whenever I am injecting testosterone/hcg. It's like my body doesn't want to accept the testsoteroneand hcg. Hcg is not reacting the way it used to. My body is tired as hellburthe minds not to able to shutoff. I am not able to sleep.its 03:30 am here in my country I am still awake.
I am consedring stopping trt cold turkey now. Regarding e2 valerate. I did try oral 2 mg, No relief. Still wary of using the injectable or gel version as I don't wanna inject any more chemicals in my body but a better insight is needed from you guys. Please help me out here people. This is no way live a life.
I am consedring stopping trt cold turkey now. Regarding e2 valerate. I did try oral 2 mg, No relief. Still wary of using the injectable or gel version as I don't wanna inject any more chemicals in my body but a better insight is needed from you guys. Please help me out here people. This is no way live a life.
Nelson Vergel
Founder, ExcelMale.com
Here is a good summary: Anastrozole (Arimidex) Real-World Member Experiences from ExcelMale.com
t_spacemonkey
Well-Known Member
I would not stop TRT. lower dose maybe, stick to 100mg/week or in that range. also keep lower dose HCG. where is your DHT level at? as mentioned in prev post, try DHT enanthate from 5ar, at like 2x10-20mg/week. e2 pills also suck and 2mg is way too high for most people.
I would also try to raise allopregnanolone levels (not pregnenelone), you can do it in a few ways. the most straightforward is 10-30mg injections from 5arsociety. another cheaper reliable way is to take PEA supplement+pregnenolone together - i takes a few weeks but works. good luck
Hans Amato has some good info on all things DHT; Does PEA really increase DHT
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