silverlining
New Member
TL;DR: Long PFS history since Nov 2023 (fin crash → partial recovery on TRT for over a year, doing well). In June 2026 added anastrozole (3-4 doses over ~3 weeks) to a 300mg test + masterone protocol → crushed my E2. Dropped test dose from 200mg to 100mg/week in July to try to fix the T:E2 gap, added HCG 500iu EOD. ~20 days later developed a new, severe symptom cluster: joint pain, dry mouth/lips/skin, frequent urination, worsened tinnitus, insomnia (new — never had this before), full-body muscle twitching, increased body hair, worse speech/brain fog/anxiety, flu-like symptoms, cold hands/feet. Not sure if this is a fresh crash from the AI, or from dropping test dose (less substrate to aromatize), or both. Scared this is Post-AI Syndrome / permanent. Need input from anyone who's navigated this.
Background: PFS since Nov 2023 (fin, even short low-dose exposure, crashed me hard each time confirmed on rechallenge). Recovered substantially through 2024 on no treatment. Started TRT Jan 2025 (200mg/week) for residual Pre mautre ejaculation did very well on it for over a year, best I'd felt since PFS onset, aside from persistent tinnitus. Ran 500mg/week + masterone briefly in late 2025, no issues. Back to 200mg/week through early 2026.
What changed June 2026: Bumped to 300mg test + 100mg masterone/week, added 0.25-0.5mg anastrozole only for 2 weeks, 3-4 AI doses total. Masterone gave no results (possibly already acting as a mild anti-estrogen itself), and between that and the AI I believe I crushed my E2.
July 2026 the new crash: Developed severe anxiety, no dopaminergic response, libido gone, genital numbness/no blood flow, cold glands. Bloods: TT ~2000 ng/dl, E2 only 46 pg/ml at trough (should be closer to 100 on that dose given my normal ~20:1 TT:E2 ratio). Cut test dose 200→100mg/week to close the gap, added HCG 500iu EOD (helped briefly, now stopped helping).
~20 days after the dose cut, new symptoms appeared: joint pain (elbows, knees), dry mouth/lips/scalp/face, dry foreskin, frequent urination, tinnitus spiking, new insomnia/fragmented sleep (never had this before), full-body muscle twitching, increased body hair growth, worse speech and brain fog, flu-like symptoms with runny nose, cold hands/feet. Losing muscle and glycogen fast.
My question : Is this a continuation of the AI crash, or is it a separate effect of dropping my test dose (less aromatizable substrate on top of an already-suppressed E2)? Everything was stable from 2024 until I touched anastrozole in June I'd used it before on a 500mg/week blast without any issue like this. Should I come off test entirely, go back up in dose to give E2 more room to aromatize, or hold and wait it out? Has anyone recovered from a crash like this, especially the joint pain / insomnia / dry mucous membrane cluster?
I've read about people developing permanent estrogen receptor damage from AI use and it terrifies me I know of a few people in this community who didn't make it through something similar. I had clawed my way back to feeling mostly normal by June after years of this, and losing that in a month has been brutal. If anyone has real experience with this or if anynoe can give me any guidance what should i do next? should i increase the testosterone to make room for aromitastion or should i stop the testostreone altogether or should i change ester the for faster aromitastion or should i add dbol or e2 valerate to increase my e2?? please help me i cant continue like this. i Used to so handsome and happy before but this low/crsuhed e2 has taken life out of my body. i dont find joy in anything, i cry everyday seeing my body like this. One thing i know is that i had got better from the pfs crash with time but this time i am on exogenous testosterone i dont know what should i do alleiviate my symptoms? Please help me, Please !
Background: PFS since Nov 2023 (fin, even short low-dose exposure, crashed me hard each time confirmed on rechallenge). Recovered substantially through 2024 on no treatment. Started TRT Jan 2025 (200mg/week) for residual Pre mautre ejaculation did very well on it for over a year, best I'd felt since PFS onset, aside from persistent tinnitus. Ran 500mg/week + masterone briefly in late 2025, no issues. Back to 200mg/week through early 2026.
What changed June 2026: Bumped to 300mg test + 100mg masterone/week, added 0.25-0.5mg anastrozole only for 2 weeks, 3-4 AI doses total. Masterone gave no results (possibly already acting as a mild anti-estrogen itself), and between that and the AI I believe I crushed my E2.
July 2026 the new crash: Developed severe anxiety, no dopaminergic response, libido gone, genital numbness/no blood flow, cold glands. Bloods: TT ~2000 ng/dl, E2 only 46 pg/ml at trough (should be closer to 100 on that dose given my normal ~20:1 TT:E2 ratio). Cut test dose 200→100mg/week to close the gap, added HCG 500iu EOD (helped briefly, now stopped helping).
~20 days after the dose cut, new symptoms appeared: joint pain (elbows, knees), dry mouth/lips/scalp/face, dry foreskin, frequent urination, tinnitus spiking, new insomnia/fragmented sleep (never had this before), full-body muscle twitching, increased body hair growth, worse speech and brain fog, flu-like symptoms with runny nose, cold hands/feet. Losing muscle and glycogen fast.
My question : Is this a continuation of the AI crash, or is it a separate effect of dropping my test dose (less aromatizable substrate on top of an already-suppressed E2)? Everything was stable from 2024 until I touched anastrozole in June I'd used it before on a 500mg/week blast without any issue like this. Should I come off test entirely, go back up in dose to give E2 more room to aromatize, or hold and wait it out? Has anyone recovered from a crash like this, especially the joint pain / insomnia / dry mucous membrane cluster?
I've read about people developing permanent estrogen receptor damage from AI use and it terrifies me I know of a few people in this community who didn't make it through something similar. I had clawed my way back to feeling mostly normal by June after years of this, and losing that in a month has been brutal. If anyone has real experience with this or if anynoe can give me any guidance what should i do next? should i increase the testosterone to make room for aromitastion or should i stop the testostreone altogether or should i change ester the for faster aromitastion or should i add dbol or e2 valerate to increase my e2?? please help me i cant continue like this. i Used to so handsome and happy before but this low/crsuhed e2 has taken life out of my body. i dont find joy in anything, i cry everyday seeing my body like this. One thing i know is that i had got better from the pfs crash with time but this time i am on exogenous testosterone i dont know what should i do alleiviate my symptoms? Please help me, Please !
