PDE-5 INHIBITORS AND CARDIAC HEALTH SYMPOSIUM 2023

[madman]

Princeton4 - 2023

www.eventdex.com

Burnett, Mulhall, Goldstein, Parish, and Kim!

 

[madman]

If you are interested in watching the lectures!

Cardiovascular Safety and Benefits of PDE-5 Inhibition in Women with Female Sexual Dysfunction (FSD): Summary of Findings from Clinical Trials of PDE-5 Inhibition in Women

Speaker Name and Title: Irwin Goldstein MD The Princeton 4 meeting was sponsored by an unrestricted grant from Sanofi. Sanofi was not involved in choosing the content or speakers for the meeting. Affiliation of the speaker: San Diego Sexual Medicine Alvarado Hospital, San Diego, CA University...

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Cardiovascular Safety and Benefits of PDE-5 Inhibition in Women with Female Sexual Dysfunction (FSD) - Excel Male Health Forum

www.excelmale.com

Is ED an Independent Risk Factor or Risk Marker for CVD and What Is the Role of CT Calcium Scoring? - Excel Male Health Forum

www.excelmale.com

Diagnostic and Treatment Guidelines for FSD in Women - Excel Male Health Forum

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Erectile Dysfunction: Second and Third Line Therapies - Excel Male Health Forum

www.excelmale.com

Update on the Psychological Impact of ED and ED Therapy - Excel Male Health Forum

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Is There a Role for Topical or Oral PDE-5 Inhibition in Treating Female Sexual Dysfunction (FSD)? - Excel Male Health Forum

www.excelmale.com

Are PDE-5 Inhibitors Cardioprotective? - Excel Male Health Forum

www.excelmale.com

Safety of PDE-5 Inhibitors with Antihypertensive Medicines and Nitrates - Excel Male Health Forum

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Mechanisms of Action of PDE-5 Inhibitors: Basic Science Concepts - Excel Male Health Forum

www.excelmale.com

Do Younger Men with ED Have Greater Risk of Cardiovascular and All-Cause Mortality? - Excel Male Health Forum

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Is the Princeton 3 Algorithm Still Correct, and What Is the Role of Telemedicine? - Excel Male Health Forum

www.excelmale.com

Forum list

The Most Respected Testosterone TRT Men's Health Forum Since 2013

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[madman]

Long-term Effects of PDE5i on Cardiovascular Outcomes and Death - Excel Male Health Forum

*This is the first meta-analysis to fully assess the long-term effects of PDE5i on hard cardiovascular endpoints. The major finding of our analysis is that the use of PDE5i is associated with a reduction of 22% in MACE and 30% in all-cause mortality primarily in middle-aged men with a rather...

www.excelmale.com

 

[madman]

Thread 'Tadalafil Use in Cardiovascular Disease'

Mar 2, 2025

Abstract

Tadalafil is a phosphodiesterase inhibitor currently approved for use in erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). While tadalafil’s benefits in ED and BPH have been well-established for years, its benefits in PAH were identified only recently in major clinical trials, resulting in the recent approval of a single tablet, combination therapy of tadalafil with an endothelin receptor antagonist for PAH. With Tadalafil’s cardiovascular benefits in ED, BPH, and PAH, clinical researchers have begun investigating...

• madman
• tadalafil; nitric oxide; cvd; ed; pah
• Replies: 10
• Forum: Health & Wellness

 

[madman]

Thread 'Managing Erectile Dysfunction & Heart Health'

Jul 18, 2025

Dr. Dapo lluyomade

* I think erectile dysfunction, we should really begin to think of erectile dysfunction as subclinical atherosclerosis until proven otherwise

Is your patient’s sexual dysfunction an early indicator of serious cardiovascular disease? In this episode of BackTable Urology, Dr. Amy Pearlman teams up with preventative cardiologist Dr. Dapo Iluyomade to discuss the relationship between erectile dysfunction (ED) and cardiovascular disease, and the holistic approach needed to prevent both of these chronic conditions from...

• madman
• ed; cvd; testosterone/hrt; health
• Replies: 11
• Forum: Health & Wellness

 

[madman]

Thread 'Muscle Mass, Testosterone & Erections: The Doctor's Blueprint for Men’s Health'

Aug 12, 2025

* the best overall marker for overall health in men is ERECTILE FUNCTION


* One of the most striking points from the discussion was Dr. Kohler’s perspective on erectile dysfunction (ED). He described it not just as a sexual problem, but as one of the earliest "check engine lights" for heart disease. The blood vessels to the penis are smaller than those in the heart, so plaque buildup (atherosclerosis) affects them first. Persistent erection issues can signal vascular problems that may soon affect your heart.

...

• madman
• ed; cvd; testosterone/hrt; health
• Replies: 9
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'Erectile dysfunction: A vital sign for cardiovascular health'

Aug 15, 2025

* The P4 panel recommendations confirm that ED is a strong, independent predictor of cardiac events, even when traditional risk factors such as cholesterol, diabetes and blood pressure are controlled for. In short, ED is the body's "check engine light" for heart disease.


* Phosphodiesterase-5 (PDE5) inhibitors — such as sildenafil and tadalafil — remain first line therapy for ED. The P4 recommendations, however, suggest that these medications may offer more than symptom relief. Multiple large studies show that men taking PDE5 inhibitors have lower rates of heart...

• madman
• ed; cvd; princeton4; pde5i
• Replies: 6
• Forum: Health & Wellness

 

[madman]

Thread 'Struggling with ED? Dr. Jeff Albaugh Breaks Down Causes, Treatments, and How to Take Back Control'

Aug 18, 2025

Great presentation!

I have been stressing this numerous times over the years.

ED is multifactorial and vascular issues are the most common cause.

Stop getting caught up on T, DHT, estradiol let alone the myth that one needs high FT/DHT!

T plays a small role.




What about testosterone?

* testosterone is a hormone that works all over the body and it has a small role with erections but it has a big role with libido or sex drive so it is important but the key essential components is blood flow and nervous conduction


* deep sleep is critical to...

• madman
• ed; cvd; causes/treatments; testosterone
• Replies: 7
• Forum: Health & Wellness

 

[madman]

Thread 'Penile Doppler Explained: Normal Study vs Arterial Insufficiency and Venous Leak'

Aug 23, 2025

Penile Doppler ultrasound is a vital tool for evaluating vascular causes of erectile dysfunction. In a normal study, adequate arterial inflow is demonstrated by a peak systolic velocity (PSV) greater than 30–35 cm/s, and proper venous occlusion is confirmed by a low end diastolic velocity (EDV) approaching zero. This pattern supports the achievement and maintenance of a firm erection. In contrast, the abnormal case shows a PSV less than 25 cm/s, indicating arterial insufficiency, and a persistently elevated EDV of 5–9 cm/s with continuous diastolic flow...

• madman
• penile doppler us; ed; vascular; imaging technique
• Replies: 11
• Forum: Health & Wellness

 

[madman]

Thread 'Cardiovascular Pharmacotherapy & Male Sexual Function'

Oct 25, 2025

Prof. Dr. Mahmoud Tantawy

• madman
• ed; cvd; pharmacotherapy; cardiovascular health
• Replies: 16
• Forum: When TRT Is Not Enough (ED, Libido, & More)

 

[madman]

Thread 'The interplay of health and heart health on sexual function: understanding the impact of CVD on sexual dysfunction in men'

Oct 26, 2025

* Erectile dysfunction is a marker of underlying cardiac disease, but many doctors are just not asking!




@Nelson Vergel

This is powerful!

6:00-6:15

* You need to lose about 75% of the lumen of the coronary artery before you get your first cardiac symptom but if you lose even a small amount of the very small penile artery you get sexual problems

https://vimeo.com/1100857015?share=copy&fl=cl&fe=ci
VIDEO HERE

Dr. Mike Kirby

Summary

Take Home Message

• madman
• ed; cvd; cardiovacular health
• Replies: 21
• Forum: When TRT Is Not Enough (ED, Libido, & More)