Oral Testosterone vs Daily Cyp/Prop Injection

Hello all (@madman, @Cataceous, @Nelson Vergel @Systemlord ),

I'm trying to figure out the benefit of Oral Testosterone Capsules (Tlando, Jatenzo, etc) vs Daily Test Cyp/Prop Injection. Does anyone have a point of view on this or data to support one or the other?

Thanks in advance for your time and advice.

Main diffrence is the PKs between the different formulations (esterified injectable T vs oral).

Advantages/disadvantages to each depending on your goals.




Look over all the threads in post #31
 
I have personal anecdotal evidence on Tprop. my dose is 30mg/daily. i noticed increased libido, better mood. I believe the shorter half life mimics a natural cycle a bit better, and high sustained levels are not optimal

I agree that daily fluctuations in T can be advantageous for many but even than keep in mind that other than hitting a daily peak/trough TP in no way mimics the natural endogenous 24 hr circadian rhythm of a healthy young male.

The T-patch (Androderm) applied before bed would be the only T formulation which would most closely mimc this.

One of the main downfalls with injections especially when using the medium acting esters (TC/TE) whether injecting once weekly, twice-weekly, M/W/F, EOD or daily is most are running high/absurdly high FT levels steady-state 24/7.

Most are still hitting high/absurdly high trough FT levels on such protocols.

The body ws never meant to be amped up on T 24/7.
 
I'm trying to figure out the benefit of Oral Testosterone Capsules (Tlando, Jatenzo, etc) vs Daily Test Cyp/Prop Injection. Does anyone have a point of view on this or data to support one or the other?
If you want consistency in hormone levels, day to day, Jatenzo is for you. I felt steady at 7 days.

The recommended starting dosage for Jatenzo is 237 mg.
 
I have personal anecdotal evidence on Tprop. my dose is 30mg/daily. i noticed increased libido, better mood. I believe the shorter half life mimics a natural cycle a bit better, and high sustained levels are not optimal
But in taking four times a typical TRT dose you surely do have "high sustained levels", probably each day varying from high to extremely high.
 
I have personal anecdotal evidence on Tprop. my dose is 30mg/daily. i noticed increased libido, better mood. I believe the shorter half life mimics a natural cycle a bit better, and high sustained levels are not optimal
Whats your total T, Free T, estrogen and SHBG on such a protocol?
 
900 ng total
30 free
11 shbg
e2 sensitive 60
before injection so they are prob a bit higher before

You left out some of the most important blood markers, RBCs, hemoglobin and hematocrit.

As you can see due to running a high-end TT 900 ng/dL with a very low SHBG 11 nmol/L you are hitting an absurdly high FT level.

Well beyond where a healthy young male would be in his prime and this is a short-lived peak not steady-state.

If you feel great overall and are not struggling with any sides than I see no issues.

210 mg T/week let alone 30 mg TP injected daily would be overkill for most.

100 mg TP = 83 mg T (no ester)

10 mg TP = 8.3 mg T

30 mg TP is a whopping daily dose of T.

Average daily T production healthy young male 5-7 mg.

Not sure how long you have been on your protocol but you need to keep in mind that where your hematocrit sits 4-12 weeks in is not where it will end up as it can take anywhere from 6-9 months and in some cases up to a year to reach peak levels.

Many tend to overlook this.


 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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