Oral Testosterone for All: Why Diet Alone Won’t Fix Your Health

madman

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In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to break through the testosterone misinformation that’s kept millions suffering. They unpack the real causes of the global testosterone crisis—including endocrine disruptors, poor sleep, processed food, and outdated fears around steroids and toxic masculinity. You’ll learn why testosterone matters for both men and women, how it powers dopamine, mitochondrial health, sleep, libido, and mood—and why “natural” testosterone boost methods usually fail. Dave and Shalin reveal how biohacking hormone health is evolving, and how new oral testosterone therapy (Kyzatrex®) is rewriting the rules with safer, more effective delivery—no injections, creams, or risky side effects.




What You Will Learn in This Episode:


• Why testosterone matters for men and women at every age
• The real causes of the global testosterone crash
• How testosterone misinformation and steroid stigma block effective treatment
• Why diet, sleep, and exercise cannot fully fix low testosterone
• Low testosterone symptoms most people ignore
• How testosterone drives dopamine, motivation, sleep, and mitochondrial health
• The breakthrough that makes oral testosterone safe and effective
• How Kyzatrex® lowers SHBG and boosts free testosterone naturally
• Why restoring testosterone is key to libido, brain health, and longevity
• How to use testosterone therapy safely—without suppressing fertility




Timestamps:

00:00 Trailer
00:52 Introduction
01:29 Global Decline in Testosterone Levels
02:27 Symptoms of Low Testosterone
03:48 Personal Journey with Testosterone Therapy
05:06 The Role of Testosterone in Overall Health
06:18 Testosterone Levels in Men and Women
08:48 Challenges and Innovations in Testosterone Delivery
16:25 The Importance of Circadian Rhythm in Testosterone Therapy
19:19 The Future of Testosterone Therapy
32:00 Investment and Development in Testosterone Therapy
34:57 Introduction to FDA and Hormone Replacement
35:31 FDA’s Impact on Women’s Health
36:10 Testosterone and Cardiovascular Risk
39:05 Testosterone and Depression
40:30 Testosterone Testing and Misconceptions
44:58 The Testosterone Project and Female Hormone Therapy
47:51 Testosterone’s Role in Longevity and Health
55:37 Cost and Accessibility of Testosterone Therapy
01:04:03 Conclusion and Final Thoughts
 
 
Have you tried Kyzatrex? I have an appointment coming up in 10 days and may ask for a trial. For some reason my levels went down 50% after getting a new compounded prescription. Been going trough hell with levels dropping.
 
Have you tried Kyzatrex? I have an appointment coming up in 10 days and may ask for a trial. For some reason my levels went down 50% after getting a new compounded prescription. Been going trough hell with levels dropping.

No harm in trialing oral TU an even then if it does not work out you can jump back on injections as the half-life of oral TU is fairly quick!

I live in Canada.

My reply from another thread:



Last year Verity Pharmaceuticals submitted oral Tlando Approval to Health Canada and not too long after Marius Pharmaceuticals did the same for Kyzatrex.

Chances are sometime this year Kyzatrex and Tlando will be available to Canadians.

Even than although there are many advantages when it comes to the PK profile, side-effects let alone delivery route I have no interest in pursuing such.

Started on injectable esterified T from the get-go back in 2016!
 
I have listened to portions of the Dr. Khera interview and it was interesting that he thought a total of 400 to 450 reached saturation. My only concern with Kyzatrex is I go from a long ester (test C) to a peak followed by a very low trough with orals. Not sure I quite get how such a low wouldn't cause issues? Cautecous has me interested in Test C and Test P separate shots too but with that a person can maintain a decent trough. Any thoughts on the low with Kyzatrex? I just know that I need a TT of around 500 and a trough around 150 free and I'm good. Struggling right now with new vials as my free and total crashed and it's been hell the last 3 weeks. Labs supported how I'm feeling too.
 
I have listened to portions of the Dr. Khera interview and it was interesting that he thought a total of 400 to 450 reached saturation. My only concern with Kyzatrex is I go from a long ester (test C) to a peak followed by a very low trough with orals. Not sure I quite get how such a low wouldn't cause issues? Cautecous has me interested in Test C and Test P separate shots too but with that a person can maintain a decent trough. Any thoughts on the low with Kyzatrex? I just know that I need a TT of around 500 and a trough around 150 free and I'm good. Struggling right now with new vials as my free and total crashed and it's been hell the last 3 weeks. Labs supported how I'm feeling too.

No one can say how you will react to an oral TU protocol let alone what peak/trough level will be achieved.

The only way to know is to give it a go.

The downfall for many especially the men living on the so called HRT/men's health forums is that most are overmedicated on T stuck on that more T is better mentality bullSHIT!

Everyone and their brother gunning for these high let alone absurdly high trough FT levels let alone their T levels are jacked up steady-state 24/7.

T was never meant to be jacked up 24/7 let alone beyond/well beyond your genetic natty set-point!

Going to be a big transiton going from jacked up T levels 24/7 to an oral TU protocol where you are only hitting fairly short-lived peaks 2-4 hrs post dose only to be followed by much lower trough levels as in close to or back to baseline 8-12 hrs later.

2 daily peak/troughs.

Unfortunately these men would need to bite the bullet and expect a bumpy transition which may take a few months for the body to adapt.

Although steady state will be achieved much faster (within a week) you would still need to give the body time to adjust to the 2 daily peaks/troughs and for many it may take a while as their bodies have been jacked up on T 24/7 steady-state and we are talking for years here in most cases!

Many will not put in the time that may be needed and bail out early claiming failure and jump right back on those beloved injections.

The men that end up jumping on oral TU when first starting therapy would most likely have an easier time let alone would be able to give the protocol a fair shake.

Yes achieving a healthy trough for the majority may be key but again when we are speaking in terms of injecting T there is a world of difference between one hitting a high-end/high trough FT following a daily vs twice-weekly vs once weekly protocol.

Many tend to overlook this which ends up causing them grief in the long run once they realize they are clearly overmedicated.

Even then many men are doing well on the newer novel formulations of oral TU putting this so called needing to run high T levels 24/7 steady-state let alone a high-end/high trough in the dirt!

Also keep in mind ARs are still lit up as T levels are declining and you are boosting your T twice daily to boot!

Dr. Mohit Khera

* activation of the receptor goes long beyond what you see in the blood

Top it all off that there is going to be less suppression of the HPG-axis on oral TU than injectables which most likely contributes to its beneficial effects especially when it comes to sides.

You have 4 options here when using oral TU.

Standard protocol dosed twice daily 12 hrs apart (AM/PM) achieving 2 peaks/troughs morning/evening.

Dr. Sun's protocol dosed twice daily 6 hrs apart (AM/NOON) still achieving 2 peaks (surge in the morning and another surge in the early afternoon but your trough time will be much longer 9-10 hrs until your next AM dose.

Also keep in mind that there is going to be less suppression og the HPG-axis on oral TU than injectables which most likely contributes to its beneficial effects.

Now in your case where you and others may be concerned with hitting too low a trough you could stay on a low weekly daily dose of TC or TE which would allow you to achieve a descent TT and more importantly FT 24/7 steady-state and throw in a low dose of oral TU once daily (AM) or twice daily such as Dr. Sun's protocol dosed twice daily 6 hrs apart (AM/NOON) which would still allow you to achive higher T levels in the morning/early afternoon due to the 2 peaks.

If you have no interest in trialing out oral TU then you could go with low dose daily TC/TE and throw in TP.




Pros/Cons oral TU (51:24-57:12)

* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline
 
Dr. Khera hitting the nail on the head!

Everyone so caught up on needing those so called high-end/high trough FT!

* activation of the receptor goes long beyond what you see in the blood




24:22-25:07

 

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