Oral Testosterone for All: Why Diet Alone Won’t Fix Your Health

[madman]

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In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to break through the testosterone misinformation that’s kept millions suffering. They unpack the real causes of the global testosterone crisis—including endocrine disruptors, poor sleep, processed food, and outdated fears around steroids and toxic masculinity. You’ll learn why testosterone matters for both men and women, how it powers dopamine, mitochondrial health, sleep, libido, and mood—and why “natural” testosterone boost methods usually fail. Dave and Shalin reveal how biohacking hormone health is evolving, and how new oral testosterone therapy (Kyzatrex®) is rewriting the rules with safer, more effective delivery—no injections, creams, or risky side effects.




What You Will Learn in This Episode:

• Why testosterone matters for men and women at every age
• The real causes of the global testosterone crash
• How testosterone misinformation and steroid stigma block effective treatment
• Why diet, sleep, and exercise cannot fully fix low testosterone
• Low testosterone symptoms most people ignore
• How testosterone drives dopamine, motivation, sleep, and mitochondrial health
• The breakthrough that makes oral testosterone safe and effective
• How Kyzatrex® lowers SHBG and boosts free testosterone naturally
• Why restoring testosterone is key to libido, brain health, and longevity
• How to use testosterone therapy safely—without suppressing fertility




Timestamps:

00:00 Trailer
00:52 Introduction
01:29 Global Decline in Testosterone Levels
02:27 Symptoms of Low Testosterone
03:48 Personal Journey with Testosterone Therapy
05:06 The Role of Testosterone in Overall Health
06:18 Testosterone Levels in Men and Women
08:48 Challenges and Innovations in Testosterone Delivery
16:25 The Importance of Circadian Rhythm in Testosterone Therapy
19:19 The Future of Testosterone Therapy
32:00 Investment and Development in Testosterone Therapy
34:57 Introduction to FDA and Hormone Replacement
35:31 FDA’s Impact on Women’s Health
36:10 Testosterone and Cardiovascular Risk
39:05 Testosterone and Depression
40:30 Testosterone Testing and Misconceptions
44:58 The Testosterone Project and Female Hormone Therapy
47:51 Testosterone’s Role in Longevity and Health
55:37 Cost and Accessibility of Testosterone Therapy
01:04:03 Conclusion and Final Thoughts

 

[madman]

Thread 'Updates in testosterone therapy - Oral T combination Therapy'

Apr 28, 2025

* Sun explains how oral testosterone formulations—thanks to their short-acting pharmacokinetics—can preserve some endogenous testosterone production, unlike traditional injections that often completely suppress it.


* He details how he customizes treatment plans by blending oral testosterone with agents like Clomiphene to boost hormonal levels without fully shutting down the body's own system, offering a more physiologically balanced solution for men who may want children in the future.


* Later, they delve into combination therapy strategies, including using oral...

• madman
• hypogonadism; oral t/kyzatrex; trt; fertility/hpta
• Replies: 2
• Forum: Testosterone and Men's Health Articles

 

[Gibbon]

Have you tried Kyzatrex? I have an appointment coming up in 10 days and may ask for a trial. For some reason my levels went down 50% after getting a new compounded prescription. Been going trough hell with levels dropping.

 

[madman]

Have you tried Kyzatrex? I have an appointment coming up in 10 days and may ask for a trial. For some reason my levels went down 50% after getting a new compounded prescription. Been going trough hell with levels dropping.

No harm in trialing oral TU an even then if it does not work out you can jump back on injections as the half-life of oral TU is fairly quick!

I live in Canada.

My reply from another thread:

Post in thread 'Oral testosterone. Who's on it?'

Feb 7, 2025

Interesting, and I visited that link and it shows only $160.

Do you visit a telemedicine clinic that sends the prescriptions to dirxhealth? If so can you provide a recommendation for one?

I live in Canada and the only oral TU option which had been available on the market for decades was the older oral TU formulation Andriol which was discontinued back in 2018.

Reports for ANDRIOL

There are 2 generic versions that replaced it but most doctors are not prescribing them due to the formulation relying heavily on a high fat intake in order to improve...

• madman

Last year Verity Pharmaceuticals submitted oral Tlando Approval to Health Canada and not too long after Marius Pharmaceuticals did the same for Kyzatrex.

Chances are sometime this year Kyzatrex and Tlando will be available to Canadians.

Even than although there are many advantages when it comes to the PK profile, side-effects let alone delivery route I have no interest in pursuing such.

Started on injectable esterified T from the get-go back in 2016!