New to TRT... so much to learn!

So I got Tuesday's lab results back. I got the sensitive estradiol test and tested for total and free testosterone since I was drawing blood anyway.
Four days after my first and only injection (67 mg/ml) total T was 1179 ng/dl (264-916), free was 21.4 pg/ml (8.7-25.1), and estradiol was 22.5 pg/ml (8-35). Still had high levels of testosterone after four days, estradiol seems like a pretty good number considering T is pretty high.
This leads me to believe I've got a low baseline estrogen level seeing as that number should be elevated after the injection? Maybe my issues (low libido, irritability, mood swings) stem from low estrogen levels? Honestly I have felt pretty damn good since the injection, going to see my doc again on Monday to discuss and talk about addressing the adrenal and thyroid stuff but... thinking TRT to elevate both testosterone and estrogen levels may be a prudent course of action.
Does anyone have similar experience with naturally low estrogen causing issues? If so, how did you address? Thanks!
 
TRT is long term, and cypionate has a longish half life, meaning you don't reach steady state on a new dose for many weeks. Your reaction to a single dose really means nothing. Trying to sort all the possibilities as you are after one injection is futile. For any worthwhile assessment, you need to stay with a single protocol for at least 6-8 weeks. For me personally, when reducing dose it's more like 8-12 weeks before re-assessing symptoms and getting labs.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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