New Perspectives on Micronised Purified Flavonoid Fraction in Chronic Venous Disease

madman · May 21, 2023

Hemovel- OTC Treatment for Hemorrhoid, Oral Pills for Hemorrhoids in Canada

Hemovel is an OTC treatment for Hemorrhoid that helps in reducing the duration and symptoms of Hemorrhoids.

www.hemovel.com

DorianGray · May 21, 2023

Life Extension in US has a diosmin product also they advertise for leg circulation:

Micronized Purified Flavonoid Fraction [sweet orange extract (peel) providing 450 mg diosmin, 50 mg of flavonoids expressed as hesperidin]

500 mg

Perhaps it might act similarly as Hemovel?

madman · May 21, 2023

DorianGray said:
Life Extension in US has a diosmin product also they advertise for leg circulation:

Micronized Purified Flavonoid Fraction [sweet orange extract (peel) providing 450 mg diosmin, 50 mg of flavonoids expressed as hesperidin]

500 mg

Perhaps it might act similarly as Hemovel?

Yes, the LE brand is the same as Venixxa shown in post #10

Venixxa - micronized purified flavonoid fraction (MPFF), each tablet of 500 mg contains 450 mg diosmin and 50 mg hesperidin.

*Venixxa’s active ingredient is a micronized purified flavonoid fraction (MPFF). It is composed of citrus bioflavonoids, containing 90% diosmin and 10% other flavonoids expressed as hesperidin.

Hemovel - each tablet contains 600 mg diosmin without additional flavonoids.

Both products are available over the counter in Canada.

*Flavonoids are oral venoactive drugs frequently prescribed to relieve the symptoms of chronic venous disorders (CVD). Among venoactive drugs, diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources; it can also be obtained after the conversion of hesperidin extracted from citrus rinds. Micronized purified flavonoid fraction (MPFF) is a preparation that contains mainly diosmin and a small fraction of hesperidin

DorianGray · May 22, 2023

I like the idea of using the previously described flavonoids as opposed to horse chestnut (which one vascular surgeon I know actually recommends).

@madman would you have any idea if a product like Hemovel could act synergistically with other NO supplements (thinking it might be useful as an adjunct in ED)?

madman · May 23, 2023

DorianGray said:
I like the idea of using the previously described flavonoids as opposed to horse chestnut (which one vascular surgeon I know actually recommends).

@madman would you have any idea if a product like Hemovel could act synergistically with other NO supplements (thinking it might be useful as an adjunct in ED)?

Would be a good addition as it can have beneficial effects on vascular health.

Can be costly depending on the dose used.

I take 1000 mg MPFF (900 mg diosmin and 100 mg hesperidin) split twice daily.

madman · Apr 27, 2025

Thread 'The Science Behind MPFF (Micronized Purified Flavonoid Fraction)'

Apr 27, 2025

MPFF (Micronized Purified Flavonoid Fraction) is a well-researched combination of bioflavonoids, including Diosmin and Hesperidin. For 40 years, it has been studied for its role in supporting venous and lymphatic function.

Dr. Chuback breaks down how MPFF works and why it holds a 1A recommendation from the American Venous Forum.

madman · May 3, 2025

Thread 'The Effects of Different Dosages on Micronized Purified Flavonoid Fraction’s Treatment of Lower Limb Chronic Venous Disease'

May 3, 2025

* In symptomatic chronic venous disease patients, MPFF 1000 mg once daily and MPFF 500 mg twice daily improve patient compliance, lower limb discomfort, clinical adverse events, and quality of life scores similarly.

Abstract

Background

Micronized purified flavonoid fraction (MPFF) is a widely prescribed and extensively investigated venoactive drug (VAD). The standard dosage for MPFF is 500 mg administered twice daily. However, a new daily dose of 1000 mg has just been introduced.

Objective

This study investigated whether...