Blackhawk
Member
I hope @Nelson Vergel sees this...
Background: I am currently a Leukemia patient. My type of leukemia is Chronic Lymphocytic Leukemia (CLL) which is from monoclonal B-cell mutation, i.e. B cells (lymphocytes) mutate and then self clone. Their apoptotic process is shut off by the mutation, i.e. they do not die off normally, and become senescent, i.e. non functional, but wreck havoc by secreting inflammatory chemicals. They can over multiply by factors of 100s of thousands, and displace normal cells and interfere with bone marrow, spleen and lymph node function.
Long story short, I have had progressive bone marrow failure secondary to marrow being infiltrated with the CLL cells. My bone marrow biopsy pathology stated 100% replacement with CLL cells. I have pancytopenia, meaning I have been seriously anemic and have been dependent on blood transfusions for 6 months, have had seriously decreased platelet levels which means severe bleeding risk, and have been severely neutropenic, with neutrophil levels essentially at zero for more than 4 months, which means severe immune system compromise. I have been hospitalized 5 times in the last 5 months and the last two times for infection and pneumonia due to infections and neutropenic fever due to the the compromised immune system.
And I have lost weight and muscle mass. Due to the anemia and CLL caused fatigue, I have been utterly inactive for over 5 months. It is a good day when I can be on my feet long enough to make my own breakfast.
I had a consultation with Dr Saya a few days ago. Interestingly my TRT protocol has not been able to keep up with the physiological change due to cancer and/or cancer treatment. My T, Free T and E2 levels all essentially were/are 1/2 of previous levels on a protocol I have sustained for a couple years. As such, we are increasing dose of T cyp slowly.
Dr Saya also offered Nandrolone as a possible anabolic treatment for my catabolic state. I have been reading the wide range of threads and articles on Excel male including Nelson's built to survive and find the potential for Nandrolone in my case to be compelling, both in terms of combating muscle wasting, and potentially contributing to hematopoesis which could be therapeutic for my cytopenias.
The big question in the context of cytopenia, B-cells run amok, and Nandrolone's stimulatory effect on hematopoesis; I found not very conclusive references to increased CD4 T cell increases, but nothing regarding effects on B-cells. This is a bit complicated and unclear. I don't whether there is any production of the mutated cancer cells themselves in the process of hematopoetic stem cell originated B-cells, but I do know that the main culprits in the Leukemia are self cloning mutated B-cells, which means they replicate themselves... cells created in this way did not come directly through stem cells and hematopoetic processes. So this begs the question, will taking Nandrolone lead to stimulation of mutated B-cell production/replication?
So, I have run this question by my CLL specialist/oncologist, but have yet had no answer.
In the meantime, does anyone know of any references to Nanrolone's more specific effects on hematopoesis and specifically any effect on B-cells?
Background: I am currently a Leukemia patient. My type of leukemia is Chronic Lymphocytic Leukemia (CLL) which is from monoclonal B-cell mutation, i.e. B cells (lymphocytes) mutate and then self clone. Their apoptotic process is shut off by the mutation, i.e. they do not die off normally, and become senescent, i.e. non functional, but wreck havoc by secreting inflammatory chemicals. They can over multiply by factors of 100s of thousands, and displace normal cells and interfere with bone marrow, spleen and lymph node function.
Long story short, I have had progressive bone marrow failure secondary to marrow being infiltrated with the CLL cells. My bone marrow biopsy pathology stated 100% replacement with CLL cells. I have pancytopenia, meaning I have been seriously anemic and have been dependent on blood transfusions for 6 months, have had seriously decreased platelet levels which means severe bleeding risk, and have been severely neutropenic, with neutrophil levels essentially at zero for more than 4 months, which means severe immune system compromise. I have been hospitalized 5 times in the last 5 months and the last two times for infection and pneumonia due to infections and neutropenic fever due to the the compromised immune system.
And I have lost weight and muscle mass. Due to the anemia and CLL caused fatigue, I have been utterly inactive for over 5 months. It is a good day when I can be on my feet long enough to make my own breakfast.
I had a consultation with Dr Saya a few days ago. Interestingly my TRT protocol has not been able to keep up with the physiological change due to cancer and/or cancer treatment. My T, Free T and E2 levels all essentially were/are 1/2 of previous levels on a protocol I have sustained for a couple years. As such, we are increasing dose of T cyp slowly.
Dr Saya also offered Nandrolone as a possible anabolic treatment for my catabolic state. I have been reading the wide range of threads and articles on Excel male including Nelson's built to survive and find the potential for Nandrolone in my case to be compelling, both in terms of combating muscle wasting, and potentially contributing to hematopoesis which could be therapeutic for my cytopenias.
The big question in the context of cytopenia, B-cells run amok, and Nandrolone's stimulatory effect on hematopoesis; I found not very conclusive references to increased CD4 T cell increases, but nothing regarding effects on B-cells. This is a bit complicated and unclear. I don't whether there is any production of the mutated cancer cells themselves in the process of hematopoetic stem cell originated B-cells, but I do know that the main culprits in the Leukemia are self cloning mutated B-cells, which means they replicate themselves... cells created in this way did not come directly through stem cells and hematopoetic processes. So this begs the question, will taking Nandrolone lead to stimulation of mutated B-cell production/replication?
So, I have run this question by my CLL specialist/oncologist, but have yet had no answer.
In the meantime, does anyone know of any references to Nanrolone's more specific effects on hematopoesis and specifically any effect on B-cells?
