Nandrolone effect on immunity: lymphocyte and CD4 counts

sammmy

Well-Known Member
I am a 45 yo male, with AIDS at diagnosis, but currently HIV undetectable and CD4 450 20%. I am interested in using Nandrolone to increase muscle mass. My total testosterone is in the middle of normal, SHBG about twice highest normal, and correspondingly my free testosterone is in the low normal. Although I work out 3-4 times/week, I would be described as skinny-fat.

I want to know if Nandrolone decreases your lymphocyte and CD4 counts?
Anyone with personal experience?

My main concern is that every time I try something that increases free testosterone/decreases estradiol, it causes my lymphocyte count and CD4 count to drop. Then I start having signs of HIV reactivation in the brain (where the drugs do not control it well) leading to low immunity such as unusual succeptability to cold weather, recurring cold sores, slight headaches/temperature and aching when swallowing. That happened with DHEA, Androgel, Exemestane, Proviron, HCG, Anastrozole (Arimidex), and Novedex XT. And in some of those cases, labs confirmed decreased lymphocytes and CD4 counts.
 
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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