NAD+ Supplementation for Cellular Health: Research and Experience

Hey everyone,

I've been researching NAD+ supplementation extensively and wanted to share some insights with the community here.

Why NAD+ Matters for Men's Health

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every cell of our body. It plays essential roles in:

- Energy metabolism and mitochondrial function
- DNA repair and cellular regeneration
- Sirtuin activation (the "longevity genes")
- Supporting healthy testosterone levels
- Cognitive function and brain health

The Problem: NAD+ Declines with Age

Research shows that NAD+ levels can decline by up to 50% between ages 40 and 60. This decline is associated with decreased energy levels, slower recovery from exercise, reduced cognitive sharpness, and compromised cellular health.

My Experience

I've been supplementing with NAD+ precursors for about 6 months now. The results have been noticeable - better energy throughout the day, improved workout recovery, and clearer mental focus.

Quality Matters

After trying several products, I found that purity and proper formulation make a huge difference. I've had good results with products from a company called Glunova Bio - they seem to prioritize quality control and proper dosing. You can search for them online if interested.

Questions for the Community

1. Has anyone else experimented with NAD+ supplementation?
2. What dosing protocols have worked for you?
3. Have you noticed any synergy with TRT or other hormone optimization?

Looking forward to hearing your experiences!
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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