muscle soreness due to Anastrozole?

I changed my anastrazole dosing 3 days ago from daily to .25mg weekly and the muscle soreness has virtually disappeared, (a small amount still lingering, but it may for a while). I consulted my doctor about the sensitivity level of my E2 assay and requested a "ultra sensitive" E2 assay on 22 Dec, she concurred. I can adjust as needed upon receiving those results. Thank you so much for replying to my post.


Muscle soreness is one of a number of negative sides to suppressed estrogen serum levels.

.25 mg each night is way way too much!

That could be a weekly dose NOT daily.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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