Magnesium and the Hallmarks of Aging

[ajax31]

Nutrients

. 2024 Feb 9;16(4):496.
doi: 10.3390/nu16040496.

Magnesium and the Hallmarks of Aging​

Ligia J Dominguez 1 2, Nicola Veronese 2, Mario Barbagallo 2

• PMID: 38398820
• DOI: 10.3390/nu16040496

Abstract​

Magnesium is an essential ion in the human body that regulates numerous physiological and pathological processes. Magnesium deficiency is very common in old age. Age-related chronic diseases and the aging process itself are frequently associated with low-grade chronic inflammation, called 'inflammaging'. Because chronic magnesium insufficiency has been linked to excessive generation of inflammatory markers and free radicals, inducing a chronic inflammatory state, we formerly hypothesized that magnesium inadequacy may be considered among the intermediaries helping us explain the link between inflammaging and aging-associated diseases. We show in this review evidence of the relationship of magnesium with all the hallmarks of aging (genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, disabled autophagy, dysbiosis, and chronic inflammation), which may positively affect the human healthspan. It is feasible to hypothesize that maintaining an optimal balance of magnesium during one's life course may turn out to be a safe and economical strategy contributing to the promotion of healthy aging. Future well-designed studies are necessary to further explore this hypothesis.

Keywords: aging; frailty; hallmarks of aging; healthy aging; magnesium; multimorbidity.

 

[sammmy]

Reducing the enormous complexity of aging to lack of one mineral is delusional. If it was that easy as supplying more magnesium to older people, Mother Nature would have done it already for billions years of evolution.

Nutritional medicine is currently at the level of pseudo-science. Don't believe anything that you read in nutritional "articles". Most of them are written to pretend they are doing science but have nothing to do with real science.

 

[ajax31]

i don't believe everything I read. Thank you for the condescension.

 

[Vince]

1 Mineral for Everything: Magnesium

Magnesium is a common element that has many functions in the human body, from energy production to providing bone density. It is also necessary for cardiovascular health. In fact, this simple mineral has been shown in a German study to dramatically reduce both cardiovascular disease mortality...

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