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  1. A

    Magnesium and the Hallmarks of Aging

    Nutrients . 2024 Feb 9;16(4):496. doi: 10.3390/nu16040496. Magnesium and the Hallmarks of Aging Ligia J Dominguez 1 2, Nicola Veronese 2, Mario Barbagallo 2 PMID: 38398820 DOI: 10.3390/nu16040496 Abstract Magnesium is an essential ion in the human body that regulates numerous physiological...
  2. E

    Just Started TrT and am Very Confused

    Hi, new guy here. After years of trying to combat declining T with diet, fat loss, weightlifting, etc. I finally decided to give TrT a try. At 73 years of age my T had been slowly declining to where I recently got the following report: T=328, SHBG=54.7, Free T = 4.63, Albumin 4.4. In...
  3. R

    The Men Who Age Without Erection/Sexual Issues

    My urologist said about 10% of men never experience problems with erections, even through their 70s and 80s. He said they say, "my erections are as hard as ever". Is anyone aware of data collected on these 10% of men who don't seem to have issues in their older years? Why do they succeed when...
  4. R

    What age is "normal" for a healthy man's sexual function to begin to decline?

    What age is "normal" for a healthy man's sexual function to begin to decline? I always thought it would be like age 55 or so. At age 43 here, I have the "I don't feel like I used to" feeling a lot of the time now. This has surprised me because I have had excellent sexual function my entire life...
  5. andrewBwinter

    Higher Estradiol May Help With Aging

    I found this brief clip interesting related to biological aging. I have been embracing E2 by taking boron (6 mg once per day) for a longer period of time than the suggested 2 weeks on, one week off protocol. (120 mg / wk Test-E) Since then I've had excellent results with my hip OA and a nagging...
  6. J

    TRT and Aging

    Can TRT make you age faster (skin, wrinkles, accelerated greying etc) or does it just make you look more masculine/less feminine (reduced facial fat etc)?
  7. ReillyJ

    Nitric Oxide (ED and beyond)

    My husband (THANKS TO THIS FORUM and the gentlemen on it) has his TRT dialed in nicely, his libido is good, he's being treated for severe sleep apnea going on 2 months now which i think is probably the most important thing to happen to him..he had around 65 episodes an hour and he's now down to...
  8. Nelson Vergel

    Higher IGF-1 and DHEA levels, longer telomere lengths

    Your life expectancy grows, the more anabolic – and fewer catabolic – hormones your body produces. Researchers at Harvard Medical School reached this conclusion after performing a molecular-epidemiological study on 925 men and women over the age of 54. The more anabolic hormones your body...
  9. Nelson Vergel

    Men with high levels of anabolic hormones less likely to develop worsening frailty

    The researchers found that having higher baseline levels of vitamin D, insulin-like growth factor-1 (IGF-1) and its binding protein 3 (IGFBP3) was associated with a lower risk of worse frailty status four years later. "Vitamin D, besides maintaining bone health, regulates muscle function, and...
  10. Nelson Vergel

    Why It Is Harder To Add Muscle Mass As We Age?

    We lose muscle mass and strength as we age. This is known as sarcopenia. Muscle loss could begin in our 30s. Genetics and lifestyle play a major factor and there is a lot of inherited individual variability There are several reasons why we become weaker: Our nervous system becomes more...
  11. Nelson Vergel

    Will Metformin Become the First Anti-Aging Drug?

    A committed group of scientists is seeking to validate metformin as the first-ever anti-aging medication.1,2 In this day of staggering drug prices, metformin is available as a low-cost generic. One mechanism by which metformin works is by activating AMPK, an enzyme inside cells that lowers...
  12. Nelson Vergel

    Review of Studies: Sleep and Human Aging

    Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity and quality occur as we age, and are there functional consequences? What are the underlying neural mechanisms that explain age-related sleep disruption? This review tackles these questions. First, we...
  13. Nelson Vergel

    Male hormone reverses cell aging in clinical trial

    “One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces,” Calado said. “Each time a cell divides, its telomeres get shorter. Eventually, the cell can’t replicate anymore and dies...
  14. Nelson Vergel

    Growth Hormone Releasing Hormone and Aging

    GHRH: There are two published trials of GHRH treatment in normal aging (34, 35). Once daily GHRH injections can stimulate increases in GH and IGF-I at least to the lower part of the young adult normal range (36). In a study of 6 months treatment with daily bedtime subcutaneous injections of...
  15. Nelson Vergel

    Low morning, high evening cortisol levels tied to frailty in elderly

    “Our results suggest a link between disrupted cortisol regulation and loss of muscle mass and strength, as the underlying pathophysiology of frailty,”Hamimatunnisa Johar, a PhD student at Helmholtz Zentrum München, said in a press release. “In a clinical setting assessment of frailty can be...
  16. D

    Maintaining Muscle Mass and Aging

    Aging is inevitable. No one truly wants to accept their own mortality or the loss of their vigor and vitality. Our skin begins to lull, our hair grey's, our motor skills begin to dissipate and the battle to maintain our hormone levels becomes ever so frustrating. For men, the fact that we both...
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