Localized Prosate Cancer Patients Should Receive TRT Following Treatment

CoastWatcher

Moderator
A urologist at Queen's University, Kingston, Ontario, Canada, argues in a recent edition of "European Focus: Urology," "that a hypogonadal man with successfully treated localized prostate cancer deserves testosterone therapy (TTh/TRT) regardless of grade. The evidence is not conclusive but compelling. The story is different for those with intermediate-risk disease who, for a variety of reasons, need TTh/TRT but cannot or elect not to have treatment of their primary malignancy, but still desire androgen supplementation."

The situation for a man who finds he is dealing with intermediate risk prostate cancer is somewhat more complex. However, even men in that situation should be evaluated according to the criteria in the table presented below to determine if TRT is appropriate.

  • Competent, qualified, and interested treating physician

  • Patient able and willing to provide informed consent

  • Clinical picture compatible with diagnosis of significant testosterone deficiency

  • Serum testosterone levels supporting the diagnosis of testosterone deficiency

  • Gleason grade group <2&#8211;3

  • Disease confined to the pelvis (stage <T2c)

  • Absence of contraindications (erythrocytosis, sleep apnea, congestive heart failure)

http://www.eu-focus.europeanurology.com/article/S2405-4569(17)30161-X/fulltext

This yet another voice calling for doctors and surgeons to reconsider the long-standing aversion many have toward testosterone therapy for prostate cancer patients. The belief that TRT is absolutely contraindicated can no longer be supported.
 
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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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