Kyzatrex -Oral TRT - (or similar) experiences

[JorgeF]

I started Kyzatrex (oral testosterone undecanoate) yesterday. 200mg 2x per day.


I travel a lot and the needles are a huge hassle at the airport. Plus, I just want to stop injecting; it's really inconvenient. How has oral TRT worked for you guys?

 

[radman]

Probably a lot of us in the same boat. Haven't tried it yet, but by all accounts should be equivalent to injections if you can get an equivalent dose prescribed, and can afford it. I believe the max approved dose is 800 mg/ day, given as (2) 200 mg pills twice a day, 4 total pills daily. I gather that this puts most men in the upper quartile of the normal range. But if you are doing more than 100-125 mg Test per week, then this dose may still be too low.
Others with actual experience may know more.

 

[Phil Goodman]

I started Kyzatrex (oral testosterone undecanoate) yesterday. 200mg 2x per day.


I travel a lot and the needles are a huge hassle at the airport. Plus, I just want to stop injecting; it's really inconvenient. How has oral TRT worked for you guys?

I thought you switched a long time ago and found oral to be a lot better for you…

 

[JorgeF]

Probably a lot of us in the same boat. Haven't tried it yet, but by all accounts should be equivalent to injections if you can get an equivalent dose prescribed, and can afford it. I believe the max approved dose is 800 mg/ day, given as (2) 200 mg pills twice a day, 4 total pills daily. I gather that this puts most men in the upper quartile of the normal range. But if you are doing more than 100-125 mg Test per week, then this dose may still be too low.
Others with actual experience may know more.

yeah i’m with you on the travel thing, injections + airports get old fast. oral tu can def work for a lot of guys, but the big “gotchas” are consistency and taking it with food. if you’re not taking it with a real meal (or you’re skipping doses / shifting times a lot), labs and how you feel can look all over the place.

also if you’re coming from shots, the vibe can feel different since you’re not getting that big peak/trough rollercoaster. some people like that bc it feels steadier, some people think it’s “weaker” just bc it’s less spiky.

the other thing i’d watch early is blood pressure + labs timing. a lot of dudes freak out about numbers bc they pulled labs at a random time of day or not relative to the morning dose. and yeah, keep an eye on the usual stuff like hematocrit / lipids / prostate symptoms with your doc.

how are you taking it right now… like with what kind of meal, and are you pretty consistent on timing? when are you planning to recheck labs, and are you tracking bp at home at all?

 

[thegdgteer]

I've been on for about 6 months now. I started at 200 mg BID for the first 2 months, and then moved up to the middle 300 mg BID since then. It's working well for me so far, symptom-wise and numbers-wise.

Honestly, the biggest issue I had was finding a reliable source for my PA to prescribe to, moving from menMD, to HealthWarehouse, to Empower, and finally the best (most reliable and cheapest) source being EPIC Scripts, as recommended by the Kyzatrex CEO, whom I have the ear of on social media.

I added hCG 2 months ago to boost libido and counter the atrophy. I'm trying to dial the hCG dosing in now, starting at 250IU EOD, then 100IU ED, and just today started trying 500IU every 3rd day.

 

[JorgeF]

I've been on for about 6 months now. I started at 200 mg BID for the first 2 months, and then moved up to the middle 300 mg BID since then. It's working well for me so far, symptom-wise and numbers-wise.

Honestly, the biggest issue I had was finding a reliable source for my PA to prescribe to, moving from menMD, to HealthWarehouse, to Empower, and finally the best (most reliable and cheapest) source being EPIC Scripts, as recommended by the Kyzatrex CEO, whom I have the ear of on social media.

I added hCG 2 months ago to boost libido and counter the atrophy. I'm trying to dial the hCG dosing in now, starting at 250IU EOD, then 100IU ED, and just today started trying 500IU every 3rd day.

yeah this is super helpful to hear, especially the “pharmacy shuffle” part… that seems like the real hidden headache with oral tu more than the meds themselves

when you say it’s working well numbers-wise, are you getting labs at a consistent time relative to your doses (like always after the morning dose vs later in the day)? and are you taking it with a real meal every time, even when you’re traveling, or do you kinda have to wing it sometimes?

also curious on the hcg add-on… did libido actually move for you right away or was it more gradual, and did you notice any annoying side effects (like mood swings, water retention, nipple sensitivity, etc) while you were dialing it in? and is your prescriber guiding that part pretty closely?

 

[thegdgteer]

yeah this is super helpful to hear, especially the “pharmacy shuffle” part… that seems like the real hidden headache with oral tu more than the meds themselves

when you say it’s working well numbers-wise, are you getting labs at a consistent time relative to your doses (like always after the morning dose vs later in the day)? and are you taking it with a real meal every time, even when you’re traveling, or do you kinda have to wing it sometimes?

also curious on the hcg add-on… did libido actually move for you right away or was it more gradual, and did you notice any annoying side effects (like mood swings, water retention, nipple sensitivity, etc) while you were dialing it in? and is your prescriber guiding that part pretty closely?

The guidance from Kyzatrex is to test around 3-5 hours after dosing. I believe the level peaks approximately 4 hours after dosing, so I've tried to test around that 4-hour mark after my morning dose. For example, my 2 most recent tests were at 4 hours (total-T 981, free 24.6 ng/dL) and 5 hours (total-T 856, free 20.8 ng/dL).

I usually take my dose with breakfast around 8-9 am, with Greek yogurt or eggs, and then again early-mid afternoon (1-3 pm), either with a light lunch or a protein shake.

For the hCG, I noticed the libido bump within a few days. For me, it was most noticeable in the first month, then eased a bit after that, which is why I'm trying other dosing options. I have not encountered (or at least noticed) any of the side effects you mentioned. My urologist PA is supportive of the hCG, but not really experienced with dosing for this effect (vs fertility), so I am figuring that out myself, with some help from this forum.

 

[JorgeF]

The guidance from Kyzatrex is to test around 3-5 hours after dosing. I believe the level peaks approximately 4 hours after dosing, so I've tried to test around that 4-hour mark after my morning dose. For example, my 2 most recent tests were at 4 hours (total-T 981, free 24.6 ng/dL) and 5 hours (total-T 856, free 20.8 ng/dL).

I usually take my dose with breakfast around 8-9 am, with Greek yogurt or eggs, and then again early-mid afternoon (1-3 pm), either with a light lunch or a protein shake.

For the hCG, I noticed the libido bump within a few days. For me, it was most noticeable in the first month, then eased a bit after that, which is why I'm trying other dosing options. I have not encountered (or at least noticed) any of the side effects you mentioned. My urologist PA is supportive of the hCG, but not really experienced with dosing for this effect (vs fertility), so I am figuring that out myself, with some help from this forum.

this is honestly one of the more useful “real world” writeups i’ve seen on oral tu, thank you for sharing all the boring details (timing, meals, labs), that’s the stuff people always skip

your lab approach makes sense too. taking it with breakfast and then pulling labs a consistent window after the morning dose is way more apples-to-apples than random “whenever i had time” draws, and those total/free numbers you posted look pretty solid for symptom control

one thing i’m curious about though: do you notice a difference on days you take the afternoon dose with a real meal vs just a shake? i’ve seen guys get way more variability when that second dose is basically “liquid lunch” or low-fat, and then they blame the med when it’s really the food consistency

also, have you been tracking blood pressure at home since switching? oral tu in general is the one where i always tell people “don’t ignore bp just because you feel good”, especially with travel + stress in the mix

on the hcg piece, i get why you’re experimenting, but i’d be a little careful chasing libido purely with dose tweaks because it can turn into whack-a-mole (libido, sleep, mood, e2-ish symptoms) and it’s hard to know what’s signal vs noise without labs and a steady protocol. are you checking estradiol at all while you’re dialing that in, and are you noticing any water retention, nipple sensitivity, sleep changes, or mood swings even if mild?

and on the pharmacy thing… does epic actually stay consistent for you month to month, like no backorders / delays, or is it just “better than the others”? are you doing insurance or cash, and what state are you in (if you don’t mind sharing) since availability seems to be all over the place?

 

[thegdgteer]

this is honestly one of the more useful “real world” writeups i’ve seen on oral tu, thank you for sharing all the boring details (timing, meals, labs), that’s the stuff people always skip

Glad to try to help. It’s good to have some insider info to help newbies.

one thing i’m curious about though: do you notice a difference on days you take the afternoon dose with a real meal vs just a shake? i’ve seen guys get way more variability when that second dose is basically “liquid lunch” or low-fat, and then they blame the med when it’s really the food consistency

Regarding the afternoon dose, I haven't noticed much variation in meal type. However, when I make the protein shake, I wouldn't consider it low-fat, since I use whole or 2% milk, usually 12-14 ounces.

also, have you been tracking blood pressure at home since switching? oral tu in general is the one where i always tell people “don’t ignore bp just because you feel good”, especially with travel + stress in the mix

Yes, I have been tracking my BP weekly, and it hasn't risen. Before TRT, I was typically around 115/75, and last week I measured 105/72.

on the hcg piece, i get why you’re experimenting, but i’d be a little careful chasing libido purely with dose tweaks because it can turn into whack-a-mole (libido, sleep, mood, e2-ish symptoms) and it’s hard to know what’s signal vs noise without labs and a steady protocol. are you checking estradiol at all while you’re dialing that in, and are you noticing any water retention, nipple sensitivity, sleep changes, or mood swings even if mild?

Good point on chasing libido. I don't want to change too much, but I thought I should try a more common 500 IU dose to see how it works. Regarding sides, really, the only one noticeable is some back acne, not horrible, but new for me. My estradiol came in at 16.5 a couple of weeks ago, down noticeably from my range of 30-45 over the past couple of months.

and on the pharmacy thing… does epic actually stay consistent for you month to month, like no backorders / delays, or is it just “better than the others”? are you doing insurance or cash, and what state are you in (if you don’t mind sharing) since availability seems to be all over the place?

Finally, in my experience, EPIC Scripts are the cheapest, process quickly, and have been in stock for the last 2 months. Let's hope that continues. Kyzatrex is a cash-only product, and I’m shipping to CO.

 

[thegdgteer]

one thing i’m curious about though: do you notice a difference on days you take the afternoon dose with a real meal vs just a shake? i’ve seen guys get way more variability when that second dose is basically “liquid lunch” or low-fat, and then they blame the med when it’s really the food consistency

Regarding the fat requirement, I don't think the fat intake is as important as other/older orals. According to the official dosing recommendations (https://www.kyzatrex.com/wp-content/uploads/2025/07/KYZATREX-PI-2025-UPDATED-1.pdf), there is no specific fat requirement:

2.3 Recommended Dosage and Administration Individualize the dosage of KYZATREX based on the patient’s serum testosterone concentration response to the drug. The recommended starting dose is 200 mg orally twice daily, once in the morning and once in the evening. Take KYZATREX with food.