KYZATREX (oral testosterone undecanoate) Updates

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

www.kyzatrex.com

KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 1112. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage​

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg taken orally twice daily, once in the morning and once in the evening, with food to enhance absorption 2412. Dosage adjustments are made based on serum testosterone levels measured 3 to 5 hours after the morning dose, at least 7 days after starting treatment or following a dose adjustment 45.

Usage​

KYZATREX capsules should be taken with food. The therapy is initiated only after confirming hypogonadism through appropriate tests that show serum testosterone concentrations below the normal range. It is important to monitor blood pressure regularly due to the risk of hypertension associated with its use 1012.

Side Effects​

Common side effects include increased blood pressure, which may necessitate the use of antihypertensive medications. Other potential side effects are acne, pain at the injection site, increased red blood cell count, and mood changes. Serious side effects may include major adverse cardiovascular events such as heart attacks and strokes11517.

Price​

The price of KYZATREX can vary depending on the pharmacy, insurance coverage, and dosage. It is advisable to consult with a healthcare provider or pharmacist for the most accurate pricing information.

Efficacy​

KYZATREX has shown high efficacy in clinical trials, with up to 96% of patients achieving normal testosterone levels within 90 days of treatment. The therapy effectively manages symptoms associated with testosterone deficiency, such as fatigue, low libido, and muscle loss 367. The formulation is designed to be absorbed through the lymphatic system, reducing the risk of liver toxicity commonly associated with oral testosterone treatments 18.

Additional Considerations​

KYZATREX carries a boxed warning regarding the potential for blood pressure increases and the associated risk of cardiovascular events. It is classified as a Schedule III controlled substance due to potential for misuse and abuse 1017. It is not indicated for use in women, particularly those who are pregnant, and it is not approved for treating low testosterone due to aging19.In summary, KYZATREX offers a significant advancement in the treatment of male hypogonadism, providing a convenient oral formulation that avoids the complications of other testosterone delivery methods like injections and gels. However, careful monitoring for side effects, particularly hypertension, is crucial.

 

Thread 'Oral TU (Kyzatrex) - Breakfast + Lunch Dosing Protocol/PKs'

Apr 18, 2025

* Just to be clear when it comes to the Breakfast + Lunch Dosing Protocol/PK as Dr. Sun stated: and although this is obviously not real pharmacokinetics I just basically superimposed the two graphs on eacth other and I think that this is roughly what's happening because I've checked labs on hundreds of patients at all different time frames




7:55-13:42

• madman
• hypogonadism; oral tu/kyzatrex; tth; men's health
• Replies: 4
• Forum: Testosterone and Men's Health Articles

 

Thread 'Oral Testosterone for All: Why Diet Alone Won’t Fix Your Health'

Friday at 2:39 PM

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In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to break through the testosterone misinformation that’s kept millions suffering. They unpack the real causes of the global testosterone crisis—including endocrine disruptors, poor sleep, processed food, and outdated fears around steroids and toxic masculinity. You’ll learn why testosterone matters for both men and women, how it powers dopamine, mitochondrial health, sleep, libido, and mood—and why “natural” testosterone boost methods usually...

• madman
• hypogonadism; oral-t/kyzatrex; mens health
• Replies: 6
• Forum: Testosterone and Men's Health Articles

 

View attachment 51450

Here's an update FYI. Just out of curiosity, I did the Kyzatrex Lab test kit above. But also did Quest Lab (through Discounted Labs of Course). Both labs were completed within 1 hour of each other 8am and 9am. Values are in same format for both. Only, diff is I used LC/MS in Quest where it was not offered in Kyzatrex test. Columns didn't format with nice separation so Quest numbers noted on right

Kyzatrex - Quest

Hematocrit 39.6 (Done on ADX Card-Whole Blood - 43.7

Estradiol (Sensitive) 39.1 pg/mL - 14 (Ultrasens,LC/MS)

FSH 19.02 mIU/mL - 21.5

LH 11.3 mIU/mL HIGH 14.7
Kyzatrex shows this as high, whereas Quest puts 15.2 as high end

PSA 0.45 ng/mL - 0.20

Testosterone, Total 910 ng/dL - 764 (MS)

Testosterone, Free 170 pg/mL HIGH - 90.2 (Dialysis)
Kyzatrex uses calculated method; whereas for Quest, I ordered the dialysis.

SHBG 41.7 - 58

Albumin 4.94 g/dL

I have not been on TRT for quite awhile now. I feel good but I don't have the muscle tone I did when on TRT. I don't feel tired, but at the gym, I don't feel "go killer" like I did on TRT. Almost impossible to gain muscle mass despite working out and taking whey protein. Testicular size came back and is really good now. Libido is very good and erections as good as when on TRT. Bone density scans show very good for my age (74).

I was considering trying oral form for improvement in muscle mass but not sure it's worth it. Maybe work out harder? What do you guys think?

So, there you have it Kyzatrex lab test kit vs labs we usually get done for TRT consideration.

 

Andriol, which is oral testosterone undecanoate, has been available in Australia for a long time, more than a couple of decades. It was never very popular here. I tried it many years ago and did not feel very much from it at all unfortunately.

I read one of the warnings on this. it said not to use if you have low testosterone if you are just old, so I am out.

 

I was considering trying oral form for improvement in muscle mass but not sure it's worth it. Maybe work out harder? What do you guys think?

Two things. It sounds like you are generally in a good place so I wouldn't do anything that could make things worse. Several things to consider..

- Working out harder can often lead to overtraining which will make you go backward
- Something that has worked very well for me is adding low rep sets at near-maximal weights, but not so heavy that you have to grind the last rep out. This will increase your overall volume without crushing your recovery capacity, assuming you are eating an anabolic diet.
- On the hormone front, people doing Oral T are generally doing clomid or enclomiphene, so you might start with just that.
- Since anabolism is your goal, you could also add in a minimally suppressive compound like oxandrolone at a low dose of 10mg pre-workout3 or 4 times per week and see if the combination of these things gives you results you are happy with.

 

Two things. It sounds like you are generally in a good place so I wouldn't do anything that could make things worse. Several things to consider..

- Working out harder can often lead to overtraining which will make you go backward
- Something that has worked very well for me is adding low rep sets at near-maximal weights, but not so heavy that you have to grind the last rep out. This will increase your overall volume without crushing your recovery capacity, assuming you are eating an anabolic diet.
- On the hormone front, people doing Oral T are generally doing clomid or enclomiphene, so you might start with just that.
- Since anabolism is your goal, you could also add in a minimally suppressive compound like oxandrolone at a low dose of 10mg pre-workout3 or 4 times per week and see if the combination of these things gives you results you are happy with.

I'm that familiar with oxandrolone-will look in to that. Tried Clomid but it raised E2 significantly but did nothing for T or T free. My FSH, LH are high end, so I assume the brain is in overdrive telling the testes to ramp up production but, the Leydig cells are reduced due to age so limited in output. Does this make sense?

 

I'm that familiar with oxandrolone-will look in to that. Tried Clomid but it raised E2 significantly but did nothing for T or T free. My FSH, LH are high end, so I assume the brain is in overdrive telling the testes to ramp up production but, the Leydig cells are reduced due to age so limited in output. Does this make sense?

Yes, in that case neither clomid nor enclomiphene would likely help much. Whether they would help maintain your LH in the presence of something like oxandrolone would be matter of experimentation, but you could start without them and see.