Based on the search results provided, the main topics discussed in the Kisspeptin forum appear to be:
Kisspeptin as a Replacement for HCG in TRT
One thread discusses the potential use of Kisspeptin-10 as an alternative to compounded HCG (human chorionic gonadotropin) in testosterone replacement therapy (TRT)[1]. The discussion includes:
- How Kisspeptin acts like GnRH to stimulate the pituitary to release LH and FSH
- Questions about its effectiveness in secondary hypogonadism
- Requests for experiences from those who have tried Kisspeptin with TRT
Kisspeptin's Role in Reproduction
Several posts focus on Kisspeptin's role in regulating the reproductive system:
- Its function in stimulating GnRH release and regulating the hypothalamic-pituitary-gonadal (HPG) axis[3]
- Kisspeptin's involvement in puberty initiation, follicle development, oocyte maturation, and ovulation[3]
- Its role in male reproduction, including regulation of Leydig cells and spermatogenesis[3]
Potential Therapeutic Applications
The forum discusses various potential clinical applications of Kisspeptin:
- Treatment of idiopathic hypogonadotropic hypogonadism (iHH) and central precocious puberty (CPP)[3]
- Use in in vitro fertilization (IVF) treatments to induce oocyte maturation[5]
- Potential treatment for hypoactive sexual desire disorder (HSDD)[4][5]
- Possible applications in treating polycystic ovary syndrome, osteoporosis, and metabolic dysfunction-associated fatty liver disease[5]
Research and Clinical Trials
The forum also covers ongoing research and clinical trials related to Kisspeptin:
- Studies on Kisspeptin's effects on sexual behavior[4]
- Trials using different forms of Kisspeptin (KP-10, KP-54) and Kisspeptin receptor agonists (TAK-683, MVT-602)[5]
- Discussions about the development of Kisspeptin analogs to overcome pharmacological challenges[5]
These topics reflect the growing interest in Kisspeptin's versatile roles in reproduction, metabolism, and potential therapeutic applications.
Citations:
[1] Kisspeptin-10 as a replacement for compounded HCG?
[2] Kisspeptin - RxISK
[3] The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction - PMC
[4] Frontiers | Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction
[5] Novel therapeutic avenues for kisspeptin
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
Kisspeptin as a Replacement for HCG in TRT
One thread discusses the potential use of Kisspeptin-10 as an alternative to compounded HCG (human chorionic gonadotropin) in testosterone replacement therapy (TRT)[1]. The discussion includes:
- How Kisspeptin acts like GnRH to stimulate the pituitary to release LH and FSH
- Questions about its effectiveness in secondary hypogonadism
- Requests for experiences from those who have tried Kisspeptin with TRT
Kisspeptin's Role in Reproduction
Several posts focus on Kisspeptin's role in regulating the reproductive system:
- Its function in stimulating GnRH release and regulating the hypothalamic-pituitary-gonadal (HPG) axis[3]
- Kisspeptin's involvement in puberty initiation, follicle development, oocyte maturation, and ovulation[3]
- Its role in male reproduction, including regulation of Leydig cells and spermatogenesis[3]
Potential Therapeutic Applications
The forum discusses various potential clinical applications of Kisspeptin:
- Treatment of idiopathic hypogonadotropic hypogonadism (iHH) and central precocious puberty (CPP)[3]
- Use in in vitro fertilization (IVF) treatments to induce oocyte maturation[5]
- Potential treatment for hypoactive sexual desire disorder (HSDD)[4][5]
- Possible applications in treating polycystic ovary syndrome, osteoporosis, and metabolic dysfunction-associated fatty liver disease[5]
Research and Clinical Trials
The forum also covers ongoing research and clinical trials related to Kisspeptin:
- Studies on Kisspeptin's effects on sexual behavior[4]
- Trials using different forms of Kisspeptin (KP-10, KP-54) and Kisspeptin receptor agonists (TAK-683, MVT-602)[5]
- Discussions about the development of Kisspeptin analogs to overcome pharmacological challenges[5]
These topics reflect the growing interest in Kisspeptin's versatile roles in reproduction, metabolism, and potential therapeutic applications.
Citations:
[1] Kisspeptin-10 as a replacement for compounded HCG?
[2] Kisspeptin - RxISK
[3] The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction - PMC
[4] Frontiers | Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction
[5] Novel therapeutic avenues for kisspeptin
kisspeptin
www.excelmale.com
Kisspeptin Increases Penile Tumescence and Sexual Brain Processing in Men with HSSD - Excel Male TRT Forum
Kisspeptin Increases Penile Tumescence and Sexual Brain Processing in Men with Hypoactive Sexual Desire Disorder (2022) Ali Abbara, Paul Bech, Alexander N Comninos, Waljit S Dhillo, Natalie Ertl, Dena Ettehad, David Goldmeier, Jonathan Howard, Tia Hunjan, Beatrice Muzi, Bijal Patel, Maria...
www.excelmale.com
Kisspeptin suppression under TRT: Can it affect mood and libido? - Excel Male TRT Forum
TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men. I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be...
www.excelmale.com
Kisspeptin-10 Potential Cardiovascular risk? - Excel Male TRT Forum
Hey guys , I’d like your opinion on the studies linked below, essentially showing that Kisspeptin 10 is a major vasoconstrictor in the arteries , and is associated with inflammatory plaque response. I was prescribed Kisspeptin-10 from my clinic - and yes it’s sitting in my fridge right now-...
www.excelmale.com
The KiNG of reproduction: kisspeptin/ nNOS interactions shaping hypothalamic GnRH release - Excel Male TRT Forum
The KiNG of reproduction: kisspeptin/ nNOS interactions shaping hypothalamic GnRH release (2021) Virginia Delli, Mauro S.B. Silva, Vincent Prévot, Konstantina Chachlaki Abstract Gonadotropin-releasing hormone (GnRH) is the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, and...
www.excelmale.com
Novel therapeutic avenues for kisspeptin - Excel Male TRT Forum
Novel therapeutic avenues for kisspeptin (2022) Jovanna Tsoutsoukia, Ali Abbarab, and Waljit Dhillo Abstract Kisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin release. In...
www.excelmale.com
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding - Excel Male TRT Forum
After doing some digging since a clinic i know is no longer using hCG, a called a few pharmacies and found out they are going to be offering Gonadorelin and NOT Kisspeptin. Kisspeptin is a peptide and it is NOT approved to be compounded and states like California will not approve it, while...
www.excelmale.com
Last edited:
