Nelson Vergel
Founder, ExcelMale.com
Based on the search results provided, the main topics discussed in the Kisspeptin forum appear to be:
Kisspeptin as a Replacement for HCG in TRT
One thread discusses the potential use of Kisspeptin-10 as an alternative to compounded HCG (human chorionic gonadotropin) in testosterone replacement therapy (TRT)[1]. The discussion includes:
- How Kisspeptin acts like GnRH to stimulate the pituitary to release LH and FSH
- Questions about its effectiveness in secondary hypogonadism
- Requests for experiences from those who have tried Kisspeptin with TRT
Kisspeptin's Role in Reproduction
Several posts focus on Kisspeptin's role in regulating the reproductive system:
- Its function in stimulating GnRH release and regulating the hypothalamic-pituitary-gonadal (HPG) axis[3]
- Kisspeptin's involvement in puberty initiation, follicle development, oocyte maturation, and ovulation[3]
- Its role in male reproduction, including regulation of Leydig cells and spermatogenesis[3]
Potential Therapeutic Applications
The forum discusses various potential clinical applications of Kisspeptin:
- Treatment of idiopathic hypogonadotropic hypogonadism (iHH) and central precocious puberty (CPP)[3]
- Use in in vitro fertilization (IVF) treatments to induce oocyte maturation[5]
- Potential treatment for hypoactive sexual desire disorder (HSDD)[4][5]
- Possible applications in treating polycystic ovary syndrome, osteoporosis, and metabolic dysfunction-associated fatty liver disease[5]
Research and Clinical Trials
The forum also covers ongoing research and clinical trials related to Kisspeptin:
- Studies on Kisspeptin's effects on sexual behavior[4]
- Trials using different forms of Kisspeptin (KP-10, KP-54) and Kisspeptin receptor agonists (TAK-683, MVT-602)[5]
- Discussions about the development of Kisspeptin analogs to overcome pharmacological challenges[5]
These topics reflect the growing interest in Kisspeptin's versatile roles in reproduction, metabolism, and potential therapeutic applications.
Citations:
[1] Kisspeptin-10 as a replacement for compounded HCG?
[2] Kisspeptin - RxISK
[3] The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction - PMC
[4] Frontiers | Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction
[5] Novel therapeutic avenues for kisspeptin
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
www.excelmale.com
Kisspeptin as a Replacement for HCG in TRT
One thread discusses the potential use of Kisspeptin-10 as an alternative to compounded HCG (human chorionic gonadotropin) in testosterone replacement therapy (TRT)[1]. The discussion includes:
- How Kisspeptin acts like GnRH to stimulate the pituitary to release LH and FSH
- Questions about its effectiveness in secondary hypogonadism
- Requests for experiences from those who have tried Kisspeptin with TRT
Kisspeptin's Role in Reproduction
Several posts focus on Kisspeptin's role in regulating the reproductive system:
- Its function in stimulating GnRH release and regulating the hypothalamic-pituitary-gonadal (HPG) axis[3]
- Kisspeptin's involvement in puberty initiation, follicle development, oocyte maturation, and ovulation[3]
- Its role in male reproduction, including regulation of Leydig cells and spermatogenesis[3]
Potential Therapeutic Applications
The forum discusses various potential clinical applications of Kisspeptin:
- Treatment of idiopathic hypogonadotropic hypogonadism (iHH) and central precocious puberty (CPP)[3]
- Use in in vitro fertilization (IVF) treatments to induce oocyte maturation[5]
- Potential treatment for hypoactive sexual desire disorder (HSDD)[4][5]
- Possible applications in treating polycystic ovary syndrome, osteoporosis, and metabolic dysfunction-associated fatty liver disease[5]
Research and Clinical Trials
The forum also covers ongoing research and clinical trials related to Kisspeptin:
- Studies on Kisspeptin's effects on sexual behavior[4]
- Trials using different forms of Kisspeptin (KP-10, KP-54) and Kisspeptin receptor agonists (TAK-683, MVT-602)[5]
- Discussions about the development of Kisspeptin analogs to overcome pharmacological challenges[5]
These topics reflect the growing interest in Kisspeptin's versatile roles in reproduction, metabolism, and potential therapeutic applications.
Citations:
[1] Kisspeptin-10 as a replacement for compounded HCG?
[2] Kisspeptin - RxISK
[3] The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction - PMC
[4] Frontiers | Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction
[5] Novel therapeutic avenues for kisspeptin
kisspeptin
www.excelmale.com
Kisspeptin Increases Penile Tumescence and Sexual Brain Processing in Men with HSSD
Kisspeptin Increases Penile Tumescence and Sexual Brain Processing in Men with Hypoactive Sexual Desire Disorder (2022) Ali Abbara, Paul Bech, Alexander N Comninos, Waljit S Dhillo, Natalie Ertl, Dena Ettehad, David Goldmeier, Jonathan Howard, Tia Hunjan, Beatrice Muzi, Bijal Patel, Maria...
www.excelmale.com
Kisspeptin suppression under TRT: Can it affect mood and libido?
TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men. I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be...
www.excelmale.com
Kisspeptin-10 Potential Cardiovascular risk?
Hey guys , I’d like your opinion on the studies linked below, essentially showing that Kisspeptin 10 is a major vasoconstrictor in the arteries , and is associated with inflammatory plaque response. I was prescribed Kisspeptin-10 from my clinic - and yes it’s sitting in my fridge right now-...
www.excelmale.com
The KiNG of reproduction: kisspeptin/ nNOS interactions shaping hypothalamic GnRH release
The KiNG of reproduction: kisspeptin/ nNOS interactions shaping hypothalamic GnRH release (2021) Virginia Delli, Mauro S.B. Silva, Vincent Prévot, Konstantina Chachlaki Abstract Gonadotropin-releasing hormone (GnRH) is the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, and...
www.excelmale.com
Novel therapeutic avenues for kisspeptin
Novel therapeutic avenues for kisspeptin (2022) Jovanna Tsoutsoukia, Ali Abbarab, and Waljit Dhillo Abstract Kisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin release. In...
www.excelmale.com
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
After doing some digging since a clinic i know is no longer using hCG, a called a few pharmacies and found out they are going to be offering Gonadorelin and NOT Kisspeptin. Kisspeptin is a peptide and it is NOT approved to be compounded and states like California will not approve it, while...
www.excelmale.com
Last edited:
