Is TRT Shutting Down my Natural Production of DHEA and Pregnenolone?

psweath

New Member
I was just flagged low on some tests of both DHEA and Pregnenolone. Hence my question. Should I even be worried about it? Consider supplementing one or both to try to raise levels? Or is that pointless because the 150mg of Test Cyp I take every two weeks is shutting down production? I used to supp DHEA, but was told by some folks on an Adrenals forum (I also have low cortisol) that if I was doing TRT there was no need to supp DHEA. I also heard that DHEA lowered cortisol, so for those two reasons I discontinued it.

Anyone have any experience or thoughts on this? I see my doc on Friday to discuss, but I've found that input from friends here gives me so many good discussion points and makes my doctor meetings so much more productive.

Thanks for any ideas you might have!
Pete
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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