Is this normal, I'm not sure

[Mikey1970]

After my 3rd injection of nebido, and 6 months into trt ,my first blood test shows T of 216 nd/dl

This ain't normal is it, and anyone any idea what's going on

 

[Mikey1970]

These are my results from test

Free T4 12.8 pmol/l
TSH 1.38 mU/L
Testosterone 216 ng/dl
FSH <0.5 U/L
LH <0.2 U/L
E2 62 pmol/L

 

[CoastWatcher]

These are my results from test

Free T4 12.8 pmol/l
TSH 1.38 mU/L
Testosterone 216 ng/dl
FSH <0.5 U/L
LH <0.2 U/L
E2 62 pmol/L

Can you provide the associated ranges?

 

[Mikey1970]

Don't laugh but what does associated ranges mean

 

[Vince]

Don't laugh but what does associated ranges mean

The range of labs, (range 726 to 1,130)

 

[CoastWatcher]

The ranges are important for informed discussion since every lab establishes their own set of parameters. I will say, without fear of contradiction, that your total testosterone is wildly low. By the way, do you have SHBG values?

 

[ERO]

The bigger question is, how many weeks after your last Nebido dose were these labs drawn? I know the marketing hype says that Nebidio is good for 12 weeks between injections but real-world is typically a lot less than that. 6-8 weeks depending upon the person and the dose is more realistic in terms of maintaning a decent T level.

 

[Mikey1970]

Wildly low I totally agree as my emotions are all over the place, I'm Moody, get into an argument then crying afterwards,

7 weeks after injection I had my bloods done, and these are my results as above

I've had 3 injections all only 8 weeks apart, my endo said he'll do injections 8 weeks apart see how I do, so maybe he won't go lower than that, I've emailed him and await reply

There is obviously something wrong,

Lab ranges

Testosterone 248ng/dl to 836ng/dl
Free T4 10pmol to 20pmol
TSH 0.50 to 4.40 mU/L
FSH & LH it don't give a reference range
Neither does E2

 

[Mikey1970]

SHBG was not tested

 

[Mikey1970]

Coastwatcher when you say total testosterone, is that not my, T of 216ng/dl ?

 

[Mikey1970]

If ye can advise what tests I should take I'll go straight back to my doctor,
Also my next injection is in 4 weeks, my mate has said take 1ml nebido every 2 weeks , instead of 4ml every 8 weeks, what do you all think ,

Or is this not something to consider yet bearing in mind my level is so low after week 7

 

[ERO]

If you take a smaller dose more often you are more likely to maintain a healthy Total T level and minimize any E2 issues, so yes, 1ml every 2 weeks is highly likely to be better than 4ml every 8 weeks.

 

[Mikey1970]

thanks ero, do u think I could have another underlying issue as a cause of my T to be 216ng after week 7 of injection

 

[Mikey1970]

Even if I convinced endo to give me it every 6 weeks, going on how low it is on week 7, I'm guessing it won't be much higher on week 6

 

[ERO]

No, most likely its just how your body metabolizes Testosterone. If your SHBG is on the lower end, you go through T faster than guys that have higher SHBG. Switching to smaller amounts injected more often should make you feel a lot better.

 

[Mikey1970]

Ok, so I'll have my SHBG tested, and what do u think, when I have my next injection I might have bloods done every week for 8 weeks to see levels each week an see from that how and when I should be injecting

 

[ERO]

Every 4 weeks is often enough as long as you switch to 1ml every 2 weeks. It is clear than 4ml every 8 weeks is spaced too far apart to work well in your case, and this is likely to be true for a lot of other guys as well.

 

[Mikey1970]

Just got this info

The aveed data ref is attached note it is 3ml (750mg) same formulation as nebido which is 4 ml (1000mg) look at fig 3 watch the range in variability in subjects. Note that all men are not created eaquale http://www.fda.gov/downloads/Adviso...iveHealthDrugsAdvisoryCommittee/UCM348092.pdf

 

[Nelson Vergel]

Mikey1970

I came to this discussion late, so forgive me if I do not see this. What dose and frequency you used? When did you get your blood test relative to last injection? How many injections total?

 

[Mikey1970]

Hi Nelson
I started Nebido 6 months ago, I've had 3 injections so far with endo agreeing them at 8 weeks apart.
This is my first blood test since starting trt, I had the blood test 7 weeks after my 3rd injection (maybe this is the issue, having said that is it normal to have such a low T week 7 especially if the norm is inject every 10weeks, I was happy my end agreed to every 8 weeks), it was 216ng, pretty low as low as pre trt,
Dose is 1000mg 4ml vial nebido every 8 weeks