Is Hematocrit of 54 Justified to Modify TRT?

Jinzang

Member
An asessment of the issue of hematocrit increase after testosterone therapy and whether current guidelines are justified. The abstract is online and the full paper can be downloaded from the link. The conclusion is:

"Testosterone therapy (TTh) can effect an increased hematocrit via poorly understood mechanisms and may have harmful effects on blood flow that differ in patient subgroups. At present, there appears no scientific basis for using a hematocrit of 0.54 to modify TTh; other values may be more appropriate in particular patient groups."
 
And make sure you are not dehydrated prior to blood draws. I consciously drink a couple glasses of water prior to blood draws and have not had to donate blood since doing so. I completely agree with BuzzSaw, if you are donating blood be sure to have your doctor order a full iron panel. Low iron in men donating blood is much more common than you would guess.
 
I cannot donate for some reason my iron does not recover. I do find eating liver will raise my iron way better than a supplement.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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