Ins and outs of testosterone: prostate cancer concerns

madman

Super Moderator

PCRI's Alex and medical oncologist Mark Scholz, MD, describe the ins and outs of testosterone, especially as it concerns men with prostate cancer concerns.


0:06 How are testosterone levels measured? When is testosterone monitoring relevant in the context of prostate cancer?
1:44 What is the normal range of testosterone for a 40-year-old man? How much and how often do testosterone levels fluctuate?
3:08 Considering that testosterone can fluctuate throughout the day, and from day to day, what is the best way to measure it?
5:44 What do "free testosterone" and "overall testosterone" mean?
9:00 What is the difference between "potency" and "libido" in this context? How can testosterone influence either one?
10:17 How do drugs like Viagra and Cialis help improve men's potency?
10:38 How often and with whom (i.e. which type of physician) should a man check testosterone levels?
11:51 Is it ever unsafe for a man to use testosterone replacement therapy?
14:58 What kind of doctor should a patient see if they are interested in testosterone replacement therapy?
 
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8:16-8:59

*the school of thought that I ascribe to is that high testosterone levels are not creating more risk of prostate cancer, prostate cancer progression, prostate cancer recurrence and that we don't really need to be really intimidated by high testosterone levels and you'll see this sometimes in people that are taking testosterone that their levels will be running a bit high so I don't focus a lot on that although other experts do and they feel that they want to control the levels in the normal range and they don't want it to be above the normal range, I ascribe to a school of thought that the high testosterone levels are not that relevant

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14:40-14:56

*generally speaking we don't give testosterone to someone who's not getting a great response but those that are those that do have undetectable PSAs its been shown unequivocally in multiple studies that you can safely administer testosterone if their own natural testosterone is not recurring


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Predict estradiol, DHT, and free testosterone levels based on total testosterone

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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