Injection...

Is there a difference if injected intermuscular or sublingual?
Yes, a big difference, injections is well an injection into muscle or fat tissue and sublingual is by mouth.

The problem with sublingual is maintaining therapeutic levels 24/7. The half-life of sublingual is 48 minutes, requiring frequent dosing throughout the day, by comparison cypionate injections half-life is 5-7 days and is typically dosed 1-2 times weekly.

Some men can’t tolerate near constant hormone levels 24/7, instead requiring a rapid peak and decline in hormones. I fall into this category.

There’s new oral options that offers a rapid peak and decline within a 12 hour period, Jatenzo dosing twice daily, few insurance companies cover it.

Creams are another option, and when done correctly, can be far superior to injections, more closely mimicking the circadian rhythm.

The majority of men on TRT use injections.
 
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Is there a difference if injected intermuscular or sublingual?
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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