In the search for libido. Started Wellbutrin XL

[M.J]

After tryin many things and hitting a wall after wall, Although b12 has a thing in it but again not sustainable and nothing compared to changing protocols.
That could be done by stopping HCG every two weeks which was the best or changing T dose. (Maybe Changing both together can be Bette ? Something to think about)

However nothing consistent yesterday I took my first Wellbutrin 150 XL in the morning cuz it may cause insomnia.

Current protocol.
20 MG EOD
509 HCG EOD
75 FSH EOD although I skipp days from time to time.

Let’s see …………

 

[M.J]

Second day

I really felt the energy from the first day, more alert and feels like I want to party all day.

Libido can’t tell yet……..

I like it…

 

[aneuman]

I do have experience after being for more than 3 years on Bupropion XL (Wellbutrin XL) 150 mg/day. At first it creates a bit of euphoria, or "good" anxiety, not different from the one I got in the third week of TRT. You are motivated to do things, have this energy that you want to put to good use, not the one that overwhelms you such as when you have anxiety. I took it for adult onset ADHD (which in hindsight might have been low T)

It tends to suppress appetite, your pulse tends to increase a little bit, it may increase libido at the beginning, particularly night time erections, but just like HCG and all the other honeymoons, it goes away after the body get's used to it and finds a new homeostasis.

That's the reason they call it the "happy, skinny, sexy pill". It blocks reuptake of norepinephrine, which is responsible for the euphoria and excess energy as well as appetite suppression, and dopamine, which gives you a sense of optimism and go-get it feeling.

Long term, as it happens, you descend into life, as things all of a sudden are normal and unexciting, like they are supposed to be. You may end up with a bit of high blood pressure (nothing major) and/or elevated heart rate, anxiety and insomnia, but again, you may not.

Don't expect miracles, unless your problem is that you don't have enough norepinephrine and dopamine and Bupropion hits it on the nail. One good thing though, if you really need an antidepressant, is that it does not cause sexual dysfunction (at least not in me) and does not have any of the horrible side effects of SSRIs (like jaw clenching, and the like). Another benefit is that I was able to leave it cold turkey without major side effects. Insomnia and anxiety were the biggest issues for me.

Polypharmacy is a bitch, and then you die. (Paraphrasing Life's a bitch....)

 

[Willyt]

I do have experience after being for more than 3 years on Bupropion XL (Wellbutrin XL) 150 mg/day. At first it creates a bit of euphoria, or "good" anxiety, not different from the one I got in the third week of TRT. You are motivated to do things, have this energy that you want to put to good use, not the one that overwhelms you such as when you have anxiety. I took it for adult onset ADHD (which in hindsight might have been low T)

It tends to suppress appetite, your pulse tends to increase a little bit, it may increase libido at the beginning, particularly night time erections, but just like HCG and all the other honeymoons, it goes away after the body get's used to it and finds a new homeostasis.

That's the reason they call it the "happy, skinny, sexy pill". It blocks reuptake of norepinephrine, which is responsible for the euphoria and excess energy as well as appetite suppression, and dopamine, which gives you a sense of optimism and go-get it feeling.

Long term, as it happens, you descend into life, as things all of a sudden are normal and unexciting, like they are supposed to be. You may end up with a bit of high blood pressure (nothing major) and/or elevated heart rate, anxiety and insomnia, but again, you may not.

Don't expect miracles, unless your problem is that you don't have enough norepinephrine and dopamine and Bupropion hits it on the nail. One good thing though, if you really need an antidepressant, is that it does not cause sexual dysfunction (at least not in me) and does not have any of the horrible side effects of SSRIs (like jaw clenching, and the like). Another benefit is that I was able to leave it cold turkey without major side effects. Insomnia and anxiety were the biggest issues for me.

Polypharmacy is a bitch, and then you die. (Paraphrasing Life's a bitch....)

Great feedback. Is microdosing Wellbutrin effective for bumping up dompamine? Or is there a minimum effective dose that must be followed?
We talk a lot about lack of dopamine being major driver for lack of libido.

 

[aneuman]

Great feedback. Is microdosing Wellbutrin effective for bumping up dompamine? Or is there a minimum effective dose that must be followed?
We talk a lot about lack of dopamine being major driver for lack of libido.

There are three versions of Wellbutrin that I know of, Wellbutrin, Wellbutrin SR and Wellbutrin XL.

You might be able to "micro dose" the original Wellbutrin version, however, SR and XL tablets should NOT be split or cut.

I'm not sure if "macrodosing" would work though. Certain medications have a minimum therapeutic dosage and in most cases require build up in the system to exert their function. This is not psilocybin.

I'm not sure if this is a "cure" for low libido. While I was on it, I felt a slight increase in libido during the first weeks, maybe a month, but then again, things have this tendency to become normal. I also do not know if "lack of dopamine" is "the" cause of low libido, it may be a factor, such as testosterone, DHT, norepinephrine, cortisol, and estradiol.

The minimum effective dosage of the XL version that I know of for depression is 150mg and the maximum dosage is 300 mg.

I were to try it "exclusively" for libido (hypothetically) I would use the original immediate release version "Wellbutrin" (not SR or XL) about 2 hour before sexual activity. I've never done it, don't know anyone who has, and I don't endorse it or recommend it. I'm simply speculating out loud.

Always follow the directions of a licensed physician before consuming any regulated drugs.

Wellbutrin side effects are:

• drowsiness
• anxiety
• excitement
• difficulty falling asleep or staying asleep
• dry mouth
• dizziness
• headache
• nausea
• vomiting
• stomach pain
• uncontrollable shaking of a part of the body
• loss of appetite
• weight loss
• constipation
• excessive sweating
• ringing in the ears
• changes in your sense of taste
• frequent urination
• sore throat

Serious side effects are:

• seizures
• confusion
• hallucinating (seeing things or hearing voices that do not exist)
• irrational fears
• muscle or joint pain
• rapid, pounding, or irregular heartbeat

Stop immediately and seek medical attention if you have:

• fever
• rash or blisters
• itching
• hives
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
• hoarseness
• difficulty breathing or swallowing
• chest pain

 

[M.J]

Thank you for your feedback, really appreciate it.
I am taking it hoping it solves my libido issue after I tried pretty much everything.

I really hope it does if not I o Ku have one last option pt141

 

[brookseth]

Wellbutrin made me tired all the time after a few months. And honestly I think it started making everything feel really "flat" too. First month or two were good and it seemed to just go down hill. I was on it for like a year and a half. Getting off of it I felt like I was going crazy for about a month or so and now that I'm off of it I feel much better overall and am glad to have stopped.

 

[M.J]

Wellbutrin made me tired all the time after a few months. And honestly I think it started making everything feel really "flat" too. First month or two were good and it seemed to just go down hill. I was on it for like a year and a half. Getting off of it I felt like I was going crazy for about a month or so and now that I'm off of it I feel much better overall and am glad to have stopped.

Reason I took it cuz I read somewhere it’s similar to addyi which is something that may increase libido but not really sure of those info.

 

[excelnelg]

I've used Wellbutrin on and off numerous times over twenty years. It's no magic cure for libido in the long term. And honestly, what boost there is is really just a bit of dopamine induced mania masquerading as libido. Over time what mostly remains is irritability and a dampening of the normal range of emotional response. Best of luck to you!

 

[M.J]

I've used Wellbutrin on and off numerous times over twenty years. It's no magic cure for libido in the long term. And honestly, what boost there is is really just a bit of dopamine induced mania masquerading as libido. Over time what mostly remains is irritability and a dampening of the normal range of emotional response. Best of luck to you!

How about withdrawal symptoms ?
There is another product called addyi it was meant for women’s libido but I read that some male patient had sole success. Do you know it ?

 

[excelnelg]

Compared to other antidepressants with horrible withdrawal symptoms, Wellbutrin has little to none. It's fairly low risk, but not no risk. I've not tried Addyi.

 

[Willyt]

Wellbutrin made me tired all the time after a few months. And honestly I think it started making everything feel really "flat" too. First month or two were good and it seemed to just go down hill. I was on it for like a year and a half. Getting off of it I felt like I was going crazy for about a month or so and now that I'm off of it I feel much better overall and am glad to have stopped.

Interesting to hear this experience because I had always people were taking Wellbutrin to minimize that flatness feeling

 

[Willyt]

Thank you for your feedback, really appreciate it.
I am taking it hoping it solves my libido issue after I tried pretty much everything.

I really hope it does if not I o Ku have one last option pt141

Keep us posted on your experiment

 

[aneuman]

Interesting to hear this experience because I had always people were taking Wellbutrin to minimize that flatness feeling

I never had that "flatness" usually associated with SSRI. I was also on Mirtazapine and never felt the "flatness" either. I stopped taking both because eventually I did not think they solved my issues, they just managed to ameliorate them temporarily, but the underlying issue was still there.

When I saw a brief and light increase in libido, I also saw a brief need t tidy up my bedroom. As I mentioned earlier, a slight overflow of energy that you want to make good use of it and a more optimistic approach, not different from what you see in the earliest stages of therapeutic dosages of TRT.

I did see the flattening effect of SSRI in my mother, RIP.

 

[Gman86]

I never had that "flatness" usually associated with SSRI. I was also on Mirtazapine and never felt the "flatness" either. I stopped taking both because eventually I did not think they solved my issues, they just managed to ameliorate them temporarily, but the underlying issue was still there.

When I saw a brief and light increase in libido, I also saw a brief need t tidy up my bedroom. As I mentioned earlier, a slight overflow of energy that you want to make good use of it and a more optimistic approach, not different from what you see in the earliest stages of therapeutic dosages of TRT.

I did see the flattening effect of SSRI in my mother, RIP.

Ya too much serotonin can cause someone to feel emotionally blunted, or flat. Can put u in a state where u don’t really care about much. But for some, that’s an improvement over being very depressed, or even suicidal

things that increase dopamine, like Wellbutrin, can tend to make someone feel more motivated and feel like they have more energy, and improve mood. Kind of like coffee, if u will. SSRI’s and dopamine agonists are very different in the way they treat mood disorders. If someone is gonna take one or the other, I would always recommend a dopamine agonists over an SSRI

 

[Gman86]

Wellbutrin made me tired all the time after a few months. And honestly I think it started making everything feel really "flat" too. First month or two were good and it seemed to just go down hill. I was on it for like a year and a half. Getting off of it I felt like I was going crazy for about a month or so and now that I'm off of it I feel much better overall and am glad to have stopped.

I’ve researched selegiline like crazy, which is used to increase dopamine, and most people feel great on it, but there are plenty of people that I’ve seen report feeling the same ways as u described. Almost always it’s due to them taking too much. U think ur dose of Wellbutrin was just too high possibly? jc. Overall I’m glad to hear that ur doing much better without it

 

[t_spacemonkey]

XL has a half life of 24h and it messed my sleep. i tried it for nicotine withdrawal and stopped after 1 pill. all psych meds will make you hate life evebtually

 

[Willyt]

I’ve researched selegiline like crazy, which is used to increase dopamine, and most people feel great on it, but there are plenty of people that I’ve seen report feeling the same ways as u described. Almost always it’s due to them taking too much. U think ur dose of Wellbutrin was just too high possibly? jc. Overall I’m glad to hear that ur doing much better without it

Selegiline still on my radar (from another thread). Going to experiment with it at some point. I know there are lots mixed reviews out there.

 

[Vestpocket]

It didn't work, at all, for me. I also tried D2 agonists.

Wellbutrin (XL) appeared to produce a paradoxical reaction, causing extreme fatigue. (Patients with this response are told to take it at night.)

Apomorphine does work, but it induces only the blood flow response via stimulating the required pathways in the brain (instead of acting directly on vasculature.) It does not cause actual desire or enhance reward, strangely enough. I take this as proof that the "increase dopamine" approach is ill informed. PT-141, similarly junky — more blood flow nonsense.

Caffeine, at high doses, provided an initial very positive response that went away after chronic use and habituation (~8 months.)

 

[Vestpocket]

That's the reason they call it the "happy, skinny, sexy pill". It blocks reuptake of norepinephrine, which is responsible for the euphoria and excess energy as well as appetite suppression, and dopamine, which gives you a sense of optimism and go-get it feeling.

The reason is that GSK actually paid prominent hosts and writers to say that. It isn't true, at all.

GSK was fined in 2012, very quietly, 3 billion dollars for the stunt. Those assertions were not backed up by any science.