Impact of TRT and Supraphysiological Testosterone Doses on Biological Aging

I've seen that some people measure their rate of aging using tools like genetic or epigenetic clocks (e.g., DNA methylation age).

I'm wondering how different testosterone dosages, from standard TRT levels up to supraphysiological doses, might affect the speed of aging as measured by these clocks.

Are there any people or studies that have measured whether aging accelerates or slows down under various TRT protocols?

I’ve also come across anecdotal reports from individuals on 200–300 mg/week of testosterone cypionate claiming they aged faster. Some mentioned getting white hair or eye rings. What could be the cause of these effects?
Could it be due to poor sleep, or are there other physiological mechanisms at play?
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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