I'm injecting 2x per week and my SHBG went up to 53 on my initial protocol of 50mg E3.5D no HCG. Now I'm in a new protocol of 80mg E3.5D+HCG 350IU E3.5D and don't know yet how my SHBG will be affected. I haven't felt any adverse side effects and blood work should be done next week. From what I have learned in this forum so far, if my SHBG still high or higher, then I should go back to injecting 1x per week. Therefore, SHBG is a deciding factor. I initially followed what everyone was doing and started at 2x per week to help control aromatase of T. Now I need to reassess given the results of my lab work. By the way, when is blood draw supposed to be done? The day of the injection before injecting?