How long for test prop to cleave off ester and become useable?

There are two steps here. After an injection the testosterone propionate must first be absorbed from the depot, which is under the skin or in a muscle. This is the slow part, with a half-life of 0.8 days. That is, it takes almost a day for half of the depot to be absorbed. There is a constant slow trickle of testosterone propionate being absorbed.

The second step occurs as testosterone propionate enters the bloodstream after absorption. There the propionate ester is cleaved from the testosterone, and the testosterone becomes available to do useful things. The removal of the ester is relatively fast, occurring within minutes of the testosterone propionate entering the blood.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
3
Guests online
1,884
Total visitors
1,887

Latest posts

Back
Top