How is intratesticular estrogen measured, and how is it treated?

[Austinite]

I'm reading too much conflicting info and hoping someone can clear this up for me.

How is intra e2 measured? And if the common aromatase inhibitors are ineffective, what's the solution?

 

[Gene Devine]

From what I've learned over the years, intratesticular E2 can't really be measured as it's not in serum and an AI is largely ineffective in controlling it.

It can be a problem for some men especially when higher doses of HCG are used in protocol.

 

[robs2nd75]

Would it present medically the same way elevated serum e2 does?

 

[Gene Devine]

Would it present medically the same way elevated serum e2 does?

Yes, my previous post was ambiguous. It is measured in serum; but for whatever the pharmacological reasons an AI does a poor job at slowing intratesticular aromatase synthesis.

 

[Austinite]

That's what is so mind boggling. I've read several studies about elevated intra E2, but none mention the method. There has to be a method if they can report results.

 

[Nelson Vergel]

We need the right amount of intratesticular testosterone and estradiol to produce healthy sperm and keep Leydig cells working properly. I have no idea why anyone would want to treat estradiol inside the testicles.