Hip Replacement Surgery on TRT- Experiences

[seppuku]

It still puzzles me. I have been on TRT for almost 40 years, have a third of the immune system of most men, have had over 10 surgeries, and not a single infection. In fact, I think I heal faster than people I know. My hematocrit is never over 53. But we are all different.

I wonder if the men with higher infections were injecting on the hip or buttock close to the surgery area.

I swapped from ventro glutes to deltoids after my surgeries - i didn't want to go anywhere near the wounds just in case.

 

[professorgreyhair]

Hi all. This is my first post. I have a question at the end (would BPC-157 help?) . I am a 68 year old male.

I am a long term TRT user, maybe for 12 years ago. Too long of that was on testogel, then 18 months or so ago I switched to sustenon settling on c1.7 ml per week. This is in the UK under doc supervision

About a year ago I was running, stuck my foot in a perfect root-trap, went flying, and broke my pelvis. I had pelvic reconstruction, a plate inserted. But unfortunately my femur went necrotic, and I had to have a total hip replacement.

Recovery has been tough. I have a permanent leg-leg discrepancy of one inch, so a permanent limp, and permanent discomfort that veers into pain from time to time. I need painkillers, strong co-codomol and a drug called metamizol. Where they help is not just with pain, but with a greater mobility of my pelvis and waist ,otherwise it feels distorted. I have physiotherapy twice a week, but the gym I find depressing because I just can't do the things i was able to do.

The other thing that has made me fed up recently is I had a Dexa scan, expecting everything to be fine and it wasn't. I was diagnosed osteopenia. I saw one rheumatologist who prescribed a drug called Profilio, but I checked it out and it seems way too powerful for me.

So, a simple question. Would it be worth trying BPC-157 to deal with the pain/immobility. Is there anything else that might work too, and/or deal with my bone density problem ?

 

[Nelson Vergel]

Thanks for sharing your story,what a rough year you've been through. Pelvic fracture, femoral necrosis, total hip replacement, and now osteopenia on top of it. Let me try to address both your pain/mobility question and the bone density issue, because they're both important.

On BPC-157

Yes, it's worth considering given your situation. BPC-157 has shown consistent results in animal models for tendon, ligament, and bone healing, as well as analgesic and anti-inflammatory effects. For musculoskeletal recovery like yours, subcutaneous injections near the affected area (200–500 mcg/day) are the typical approach. It won't correct the structural leg length discrepancy, but it may help reduce chronic inflammation and soft tissue pain around the hip and pelvis that's likely contributing to your discomfort. TB-500 (Thymosin Beta-4) is often combined with BPC-157 for musculoskeletal recovery and may add additional benefit. Access in the UK requires private sourcing, and human clinical data is still limited, so go in with realistic expectations.

On Osteopenia. Don't Overlook This

Honestly, the bone density issue deserves as much attention as the pain. The good news is that as a long-term TRT user, you have some built-in protection, testosterone plays a real role in maintaining bone density. But that only works if your levels are well-optimized. Make sure your total T is solidly above 500 ng/dL and that your estradiol isn't being over-suppressed, since estrogen is actually critical for bone in men too.

Regarding Profilio: that's primarily a polynucleotide skin/collagen treatment, and its use for osteopenia seems unusual to me. I'd seek a second rheumatology opinion before going that route.

More established approaches for your situation:

- Vitamin D3 + K2 (MK-7): Many TRT users are deficient in both. D3 at 5,000–10,000 IU daily with K2 (100–200 mcg MK-7) is a reasonable starting point. Get your 25-OH Vitamin D levels checked.
- Magnesium:Often overlooked but essential for bone metabolism.
- Bisphosphonates (e.g., alendronate):If your T-score warrants it, this is a well-established first-line treatment worth discussing with your doctor.
- **Teriparatide or Romosozumab: If bone loss is more significant, these newer agents actually build bone rather than just slow its loss, worth asking a specialist about.

On the Leg Length Discrepancy

If you haven't already, please see a good podiatrist or orthopedic specialist specifically about a shoe lift or custom orthotic. A one-inch discrepancy creates significant compensatory strain throughout your pelvis, lower back, and hip..which may be a major driver of your ongoing pain and the feeling of pelvic distortion you describe. This is a simple, underutilized fix that can make a meaningful difference.

On Exercise

I completely understand the frustration with the gym. But resistance training ,even modified, remains one of the most powerful tools for bone density. If traditional lifting is off the table right now, consider pool-based resistance work or seated/chair exercises. Even low-load mechanical stress on bone matters.

Hope this helps point you in some useful directions. Keep working with your physio and don't give up on the gym, just adapt it to where you are right now.