High levels of two hormones in the blood raise prostate cancer risk

So is a PSA of 1.8 ok for a 43 yo?

What I was 43 my PSA was 2.1.

23 years later at 65 it was 2.4. Not much change at all considering I had also been on TRT for 5 of those 23 years.

(Lately, the last 18 months, PSA has jumped around quite a bit, up to 4.2, down to 3.4, back up to 4.8 and then back down to 3.8.)
 
Could it be just inflammation or something? 2 years ago it was 0.93 then I started trt. 3 months into TRT it dropped to 0.77 with a free PSA % total of 35% and 45% which is good. But now randomly 10 months after that it's 1.8. it does feel slightly irritated due to constipation and huge bowel movements and straining which I think irritates the prostate as it's right there.
I used to be around 1.4 after trt went to 1.69, then back down to 1.46 after three month. I stopped trt after that and it went down again to 1.4.
Doing clomid now to see if it can help otherwise trying different protocol trt after this.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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