HCG loses its effect after sometime

[Tommy Wall]

Hi folks,

I have a feeling that HCG lowers is strength at the end of a month after mixing it. I mix 5000 IU only with 1ml bac water which is back loaded in a syringe. Due to this concentration each injection contains very little liquid which I prefer. My protocol is 250 IU x 3 a week. But I noticed after 3-4 weeks after a fresh mixing my nuts start to shrink. Can it be that the HCG loses its strength after sometime and if so should I increase the dosage to compensate this the weeks before having a new mix?

 

[Vince]

https://www.excelmale.com/forum/showthread.php?971-Cost-and-availability-of-HCG
EmpowerPharmacy
Expiration" in the pharmaceutical industry is defined as "The date placed on the container/labels of a drug product designating the time during which a batch of the product is expected to remain within the approved shelf life specifications if stored under defined conditions, and after which it may not be used." In other words a drug will expire once it falls outside it's acceptable specifications of pH, potency, appearance, etc the primary factor being potency. Once the active ingredient falls outside 90 - 110% its potency the medication is considered to be expired. So a drug that has 89% it's listed potency is by FDA and USP standards no longer suitable for use.

HCG is an interesting medication though... Unlike most drugs it's acceptable potency range according to its USP monograph is 80 - 125%. This is due to the fact that it is measured in International Units (IU) and not milligrams (mg). Since the analytical test to measure potency in IUs is not as accurate as the test used to measure potency by mass USP gives HCG the wider potency range. This is true of other medications measured in IUs.

Since the acceptable potency range and the therapeutic index for HCG are quite large a compounder can actually make the medication well above 100% and still be within the acceptable limits. Brand name HCG Pregnyl actually states a 60 day expiration date on it's HCG and I've tested their vials to be within 95-100% potency. You can imagine how long the expiration date would be if the HCG was made at 115% or even 125% potency.

I know compounders that have done long term stability studies on HCG showing it to be quite stable up to 90 days under refrigeration. To be conservative most compounders place 30-60 day Beyond Use Dates on their preparations just as we do. Since the Beyond Use Date starts the moment the HCG powder touches water it is important to make sure you get your HCG from a pharmacy that Freeze Dries it's HCG to prevent getting a batch that has already been reconstituted and started to degrade.

If you're interested I recommend reading more about Freeze Drying (Lyophilization) and to better understand the background of how HCG is compounded and how it works in the human body.

 

[torrential]

Tommy,

Are you keeping it cold?

 

[Tommy Wall]

Yes I keep it cold. I am thinking that it might be also an effect of that I changed my protocoll from 2x500 to 3x250 per week.

 

[Gene Devine]

HCG will maintain potency for 90 or even more if kept cold and even then the degradation is very small like 7% each month thereafter...you'll use the product up before then...

 

[Re-Ride]

The recommended dilution for 5,000 iu is 5ml. That's what the stability tests use. We'd tend to think that using less bac water is fine and that's like true but where is the study that proves this? Long shot... try 2.5 ml dilutent and see if that helps. Personally I do not find sub q any easier than im with a 30 ga so i went back to normal dilution.