HCG and inflammation

[trtthings]

Does anybody know of further studies on this? Effect of human chorionic gonadotropin on cytokine production from human endometrial cells in vitro - PubMed

I'm aware that this may not be relevant, since it's in vitro on endometrial cells, and so not even in men. But as someone who is avoiding inflammation in general (IL-6, TNFa, etc.) this doesn't sound good.

 

[trtthings]

Anyone looked into this?

@Nelson Vergel
@Cataceous
@madman

 

[Nelson Vergel]

Why would nature make women produce large amounts of hCG while pregnant? To ensure their health and their babies'.

"Human chorionic gonadotrophin (hCG) is the first specific molecule synthesized by the embryo. hCG RNA is transcribed as early as the eight-cell stage, and the blastocyst produces the protein before its implantation. hCG in the uterine microenvironment binds with its cognate receptor, luteinizing hormone/choriogonadotropin receptor (LHCGR), on the endometrial surface. This binding stimulates leukemia inhibitory factor (LIF) production and inhibits interleukin-6 (IL-6) production by epithelial cells of the endometrium. These effects ensure essential help in the preparation of the endometrium for initial embryo implantation. hCG also effects angiogenic and immunomodulatory actions as reported in many articles by our laboratories and other ones. By stimulating angiogenesis and vasculogenesis, hCG provides the placenta with an adequate maternal blood supply and optimal embryo nutrition during the invasion of the uterine endometrium. The immunomodulatory properties of hCG are numerous and important for programming maternal immune tolerance toward the embryo. The reported effects of hCG on uterine NK, Treg, and B cells, three major cell populations for the maintenance of pregnancy, demonstrate the role of this embryonic signal as a crucial immune regulator in the course of pregnancy. Human embryo rejection for hCG-related immunological reasons has been studied in different ways, and a sufficient dose of hCG seems to be necessary to maintain maternal tolerance. Different teams have studied the addition of hCG in patients suffering from recurrent miscarriages or implantation failures. hCG could also have a beneficial or a negative impact on autoimmune diseases during pregnancy. In this review, we will discuss the immunological impacts of hCG during pregnancy and if this hormone might be used therapeutically. "


In HIV, we found that HIV+ women who got pregnant had a decreased HIV viral load and their KS cancer spots disappeared. hCG is in fact a immune-modulator. Inflammatory cytokines are made by the body to actually heal. They are only damaging when produced in excess in the absence of injury.

Kaposi's sarcoma and human chorionic gonadotropin: mechanisms, moieties and mysteries - PubMed

Kaposi's Sarcoma (KS) is a highly angiogenic neoplasm associated with infection by the human gamma-herpesvirus, HHV-8 or Kaposi's sarcoma herpes virus (KSHV). When in 1872 the Hungarian scientist Moritz Kaposi described the sarcoma, which was later named after him, he was dealing with a rare...

pubmed.ncbi.nlm.nih.gov

Mystery solved of source of anti-cancer effects in pregnancy hormone

A small molecule found in pregnant women’s urine that apparently blocks the growth of several types of cancers, including AIDS-related Kaposi’s sarcoma, which currently has no cure, has been discovered by researchers. These findings resurrect a nearly 20-year controversy over whether human...

www.sciencedaily.com

 

[Cataceous]

... Effect of human chorionic gonadotropin on cytokine production from human endometrial cells in vitro - PubMed
...

Unless there's a problem with units it looks to me as though even the lowest concentration used in this experiment, 1 IU/mL, is hundreds of times greater than typical plasma levels seen in guys adding hCG to TRT, a few mIU/mL.

There are still some possible reasons to avoid doses that would equate to supraphysiological LH levels:

The Contribution of Luteinizing Hormone to Alzheimer Disease Pathogenesis - PMC

Several hypotheses have been proposed that attempt to explain the pathogenesis of Alzheimer Disease (AD) including theories involving senile plaque and neurofibrillary tangle formation, increased oxidative stress, and cell cycle abnormalities, since ...

www.ncbi.nlm.nih.gov

Potential Dangers of Higher Dose HCG? - Peak Testosterone

HCG is widely used by women as a dietary aide - it supposedly suppresses appetite - and by men for hypogonadism (clinically low testosterone)...

www.peaktestosterone.com

 

[Seth]

Unless there's a problem with units it looks to me as though even the lowest concentration used in this experiment, 1 IU/mL, is hundreds of times greater than typical plasma levels seen in guys adding hCG to TRT, a few mIU/mL.

There are still some possible reasons to avoid doses that would equate to supraphysiological LH levels:

The Contribution of Luteinizing Hormone to Alzheimer Disease Pathogenesis - PMC

Several hypotheses have been proposed that attempt to explain the pathogenesis of Alzheimer Disease (AD) including theories involving senile plaque and neurofibrillary tangle formation, increased oxidative stress, and cell cycle abnormalities, since ...

www.ncbi.nlm.nih.gov

Potential Dangers of Higher Dose HCG? - Peak Testosterone

HCG is widely used by women as a dietary aide - it supposedly suppresses appetite - and by men for hypogonadism (clinically low testosterone)...

www.peaktestosterone.com

Interesting article on HCG