HCG 1 week on, 3 weeks off ~ Dr. West Conner

Why you need HCG if you are on testosterone therapy.

Dr. West Conner recommends to his patients to only do HCG 500IU three times a week, one week on, three weeks off.

Has anyone done this protocol?

For transparency, he is a pharmacist not a medical doctor. His reasoning suggests he is concerned with the (often discussed yet never proven) notion of desensitization of the leydig cells - which wouldn’t be and isn’t a concern with the modest doses of hCG used for TRT purposes.
 
For transparency, he is a pharmacist not a medical doctor. His reasoning suggests he is concerned with the (often discussed yet never proven) notion of desensitization of the leydig cells - which wouldn’t be and isn’t a concern with the modest doses of hCG used for TRT purposes.

Would doing 1 week on, 3 off suffice? What would be the downside if any? i see an upside potentially as helping keep estrogen in check and my intuition says i would not over-stimulate leydig cells. I'm doing 'just enough' to get the job done.
 
Would doing 1 week on, 3 off suffice? What would be the downside if any? i see an upside potentially as helping keep estrogen in check and my intuition says i would not over-stimulate leydig cells. I'm doing 'just enough' to get the job done.

Suffice?

For fertility - No

For testicular atrophy - not likely (or partially)

For the subjective benefits some patients feel with HCG (libido, etc) - well for 1 week
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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