Being hypopituitary since I was 7 years old I suffered from Gynecomastia from an early age. I was put on TRT at age 50 and my pre TRT labs showed then my E2 (the womens test in Canada) was 225. I developed breasts by the time I was 10 years old. And my nipples always bothered me when young. Every shirt would irritate them, except very soft cotton t-shirts. But since starting TRT my breasts have reduced some... not a huge amount but enough that I don't feel overly nervous about it any longer. When I was young I obviously had low T and high E2.