Great T-levels (1298) but high E-levels (93.7) in follow-up BW

I bet your estradiol via ultrasensitive is less than 50 pg/mL

It depends on how much inflammation you have as measured by C Reactive Protein (CRP)
 
Thanks guys. This is the letter I sent to my TRT doc.

"As I stated before, I believe that my physician ordered the wrong estradiol test for my bloodwork. Many clinics are using the wrong estradiol test that may be over-estimating the levels of this hormone in men. An ultrasensitive estradiol test more accurately measures estradiol in men instead of the regular test that costs less. What a man wants is a sensitive estradiol test by LCMS technology. The standard test measured me at a level of 93.7. An independent second opinion told me that my estradiol via ultrasensitive is likely less than 50 pg/mL. It depends on how much inflammation I have as measured by C Reactive Protein (CRP). If you need more information concerning this topic, I am attaching a research study which compares the two methodologies when used in men.

I am steadfast and determined to not lower my TRT dosage. I believe that lowering my dosage at this point is a hasty decision. I do believe that this is the appropriate time to add in Anastrozole; because even if my estradiol is at 50, that is still probably a tad too high. However, the benefits I have experienced at a higher TRT dosage are not to be taken likely.

I have already voiced my concern to XXXXX XXXXXX with BMG corporate. Let's try to be a little more open minded in my treatment protocol. We can take small steps. "
 
Thanks Nelson. ExcelMale has definitely been a game-changer for me. I sought out this site and the accompanying FB group page long before I actually began testosterone therapy. By helping to educate before the fact and continuing to educate me during the therapy itself, it has helped to level the playing field. No longer do I accept a physician's word as gospel, particularly when it flies in the face of reason.
 
Seriously man, that T dose is too high for you. 1300 ng/dl a full week after injection is not a sustainable level. At your peak, you're going to be well out of range on total T, free T, and estradiol.

Sure, the E2 can be managed by medication, but having such high T levels will eventually lead to other health issues. Have you had your hematocrit measured recently?
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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