Getting gyno with crashed e2?

savefoxes

Member
Hi, I've been taking 160mg of T per week divided in 2 shots. I'm on week 10 right now and have been having constant nipple sensitivity and irritation for the last 3 weeks.
I was on 0.25mg of Anastrozole 2 times a weeks and then upped my dose to 0.5mg twice a week when the symptoms began and it didn't help. The sensitivity is pretty noticeable. I have a little bit of gyno from puberty and I'm afraid it might get worse. I'm 185lb 6'2 15% bf

My free T is 22, e2 is crashed. Is it possible to get nipple sensitivity from taking too much AI? What should I do?
 
I was on 0.25mg of Anastrozole 2 times a weeks and then upped my dose to 0.5mg twice a week when the symptoms began and it didn't help.
The estrogen level is one component to gyno, many other hormones are involved in the development of gyno.

That would be testosterone, prolactin and DHT that contribute to gyno. Some nipple sensitivity doesn't necessarily mean gyno.

I used to get nipple sensitivity later in the day when I was getting 654 ng/dL at 4 hours, which went on for months.

Now I'm getting 1052 ng/dL and no nipples sensitivity at all.

If you're worried about gyno you should be injecting more frequently to keep your levels more steady.
 
Last edited:
The estrogen level is one component to gyno, many other hormones are involved in the development of gyno.

That would be testosterone, prolactin and DHT that contribute to gyno. Some nipple sensitivity doesn't necessarily mean gyno.

I used to get nipple sensitivity later in the day when I was getting 654 ng/dL at 4 hours, which went on for months.

Now I'm getting 1052 ng/dL and no nipples sensitivity at all.

If you're worried about gyno you should be injecting more frequently to keep your levels more steady.

Would increasing my T level help? Should I be injecting more frequently even though my shbg is 70?
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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