Gene editing/HIV

PAUL-E

Member
The world's first gene-editing trials took place in California, involving a different technique, ZFNs. Around 80 patients with HIV had immune cells in their blood removed.
Scientists then deleted a gene called CCR5 which HIV uses to gain entry to cells. The treatment is based on a rare, gene mutation which gives some people a natural immunity to the disease.
Matt Chappell had his immune cells gene edited
One of the volunteers was Matt Chappell, 52, who has lived with HIV most of his adult life and witnessed the devastating impact that HIV/Aids has had on the gay community in San Francisco.
Matt has been off all antiretroviral medication for two years since having his immune cells gene edited.
These were small trials so caution is needed before reading too much into the results, but they are nonetheless extremely promising.

http://www.bbc.com/news/health-36439260
 
As science progresses I'm sure we will see some amazing things as long as less profitable things aren't suppressed. Example: more profitable to treat/manage than to cure.
 
What a horrible disease. I hope scientists are really getting closer to a vaccine and/or cure. And the business of the medicine doesn't get in the way of truly helping people.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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